A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh

Christine Marie George, Mary Gamble, Vesna Slavkovich, Diane Levy, Alauddin Ahmed, Habibul Ahsan, Joseph Graziano

Research output: Contribution to journalArticle

Abstract

Background: Arsenic can naturally occur in the groundwater without an anthropogenic source of contamination. In Bangladesh over 50 million people are exposed to naturally occurring arsenic concentrations exceeding the World Health Organization's guideline of 10 μg/L. Selenium and arsenic have been shown to facilitate the excretion of each other in bile. Recent evidence suggests that selenium may play a role in arsenic elimination by forming a selenium-arsenic conjugate in the liver before excretion into the bile. Methods. A cross-sectional study of 1601 adults and 287 children was conducted to assess the relationship between blood selenium and urinary and blood arsenic in a study population residing in a moderately arsenic-contaminated rural area in Bangladesh. Results: The results of this study indicate a statistically significant inverse relationship between blood selenium and urinary arsenic concentrations in both adult and pediatric populations in rural Bangladesh after adjustment for age, sex, Body Mass Index, plasma folate and B12 (in children), and ever smoking and current betel nut use (in adults). In addition, there appears to be a statistically significant inverse relationship between blood selenium and blood arsenic in children. Conclusions: Our results suggest that selenium is inversely associated with biomarkers of arsenic burden in both adults and children. These findings support the hypothesis that Se facilitates the biliary elimination of As, possibly via the putative formation of a Se-As conjugate using a glutathione complex. However, laboratory based studies are needed to provide further evidence to elucidate the presence of Se-As conjugate and its role in arsenic elimination in humans.

Original languageEnglish (US)
Article number52
JournalEnvironmental Health: A Global Access Science Source
Volume12
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Bangladesh
Arsenic
Selenium
Cross-Sectional Studies
Bile
Areca
Groundwater
Rural Population
Folic Acid
Glutathione
Body Mass Index
Biomarkers
Smoking
Guidelines
Pediatrics

Keywords

  • Arsenic
  • Bangladesh
  • Pediatric populations
  • Selenium

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh. / George, Christine Marie; Gamble, Mary; Slavkovich, Vesna; Levy, Diane; Ahmed, Alauddin; Ahsan, Habibul; Graziano, Joseph.

In: Environmental Health: A Global Access Science Source, Vol. 12, No. 1, 52, 2013.

Research output: Contribution to journalArticle

George, Christine Marie ; Gamble, Mary ; Slavkovich, Vesna ; Levy, Diane ; Ahmed, Alauddin ; Ahsan, Habibul ; Graziano, Joseph. / A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh. In: Environmental Health: A Global Access Science Source. 2013 ; Vol. 12, No. 1.
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