A cross-sectional study of Hepatitis e virus infection in pigs in different-sized farms in Northern Thailand

Soawapak Hinjoy, Kenrad Edwin Nelson, Robert V. Gibbons, Richard G. Jarman, Piyawan Chinnawirotpisan, Stefan Fernandez, Penporn Tablerk, Alain B Labrique, Prapas Patchanee

Research output: Contribution to journalArticle

Abstract

Pigs are an important reservoir of hepatitis E virus (HEV) in many countries throughout the world. We evaluated the association between farm size and presence of serum antibodies against HEV, as well as other risk factors for infection in pigs raised in Nan Province, Thailand in a cross-sectional study. The sampling frame was a total-population census of all pig herds, stratified into three classes of the farm size according to criteria developed by the Nan provincial livestock health office. One-eighth of all pigs in each farm were sampled randomly. All pig-farm owners were interviewed to elicit information on general characteristics of their farms, biosecurity and hygienic procedures, and farm management. We obtained sera and fecal samples from 879 pigs to test for antibodies to HEV and HEV RNA. Odds ratios (OR) and 95% confidence intervals (CI) for risk factors for HEV seroprevalence were estimated by multivariate logistic regression. The overall prevalence of anti-HEV immunoglobulin G antibodies was 9.9%. Pigs studied from medium-sized farms had a higher HEV seroprevalence than those from larger farms (adjusted OR 4.95, 95% CI: 1.79, 13.70). Factors associated with HEV seropositivity included feeding pigs with agro-industrial byproducts, having veterinarians on farms, and presence of other pig farms within 100 m. Twenty-five (2.9%) of 875 sampled pig stools were positive for HEV RNA. Phylogenetic analysis revealed that all HEV isolates clustered to HEV genotype 3.

Original languageEnglish (US)
Pages (from-to)698-704
Number of pages7
JournalFoodborne Pathogens and Disease
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Hepatitis E virus
Hepatitis Viruses
hepatitis
Virus Diseases
Thailand
cross-sectional studies
Swine
Cross-Sectional Studies
viruses
farms
swine
infection
seroprevalence
farm size
Seroepidemiologic Studies
odds ratio
antibodies
Antibodies
confidence interval
Farms

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Food Science
  • Animal Science and Zoology

Cite this

A cross-sectional study of Hepatitis e virus infection in pigs in different-sized farms in Northern Thailand. / Hinjoy, Soawapak; Nelson, Kenrad Edwin; Gibbons, Robert V.; Jarman, Richard G.; Chinnawirotpisan, Piyawan; Fernandez, Stefan; Tablerk, Penporn; Labrique, Alain B; Patchanee, Prapas.

In: Foodborne Pathogens and Disease, Vol. 10, No. 8, 01.08.2013, p. 698-704.

Research output: Contribution to journalArticle

Hinjoy, S, Nelson, KE, Gibbons, RV, Jarman, RG, Chinnawirotpisan, P, Fernandez, S, Tablerk, P, Labrique, AB & Patchanee, P 2013, 'A cross-sectional study of Hepatitis e virus infection in pigs in different-sized farms in Northern Thailand', Foodborne Pathogens and Disease, vol. 10, no. 8, pp. 698-704. https://doi.org/10.1089/fpd.2012.1369
Hinjoy, Soawapak ; Nelson, Kenrad Edwin ; Gibbons, Robert V. ; Jarman, Richard G. ; Chinnawirotpisan, Piyawan ; Fernandez, Stefan ; Tablerk, Penporn ; Labrique, Alain B ; Patchanee, Prapas. / A cross-sectional study of Hepatitis e virus infection in pigs in different-sized farms in Northern Thailand. In: Foodborne Pathogens and Disease. 2013 ; Vol. 10, No. 8. pp. 698-704.
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