A critical role for interleukin-1β in the progression of autoimmune diseases

Ruijuan Zhao, Hongyan Zhou, Shao Bo Su

Research output: Contribution to journalReview article

Abstract

Interleukin-1β (IL-1β) belongs to IL-1 family and is a potent pro-inflammatory cytokine. It is known to be also involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. In addition to its pathophysiologic role in host protection, IL-1β promotes the progression of a number of autoimmune diseases. Most of such diseases can be controlled by anti-IL-1β treatment. This review discusses the contribution of IL-1β to the course of autoimmune diseases, such as rheumatic diseases, uveitis, autoimmune thyroid diseases (AITD), insulin-dependent diabetes mellitus (IDDM), autoimmune inner ear disease (AIED), multiple sclerosis (MS), myocarditis, hepatitis and kidney diseases. The critical involvement of IL-1β in the pathogenesis of autoimmune diseases provides targets for developing therapeutic treatment.

Original languageEnglish (US)
Pages (from-to)658-669
Number of pages12
JournalInternational Immunopharmacology
Volume17
Issue number3
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Keywords

  • Autoimmune diseases
  • Biological therapy
  • Interleukin-1β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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