A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease

Gary P. Wormser, Franc Strle, Eugene D. Shapiro, Raymond J. Dattwyler, Paul G. Auwaerter

Research output: Contribution to journalReview articlepeer-review

Abstract

In older studies, a chronic distal symmetric sensory neuropathy was reported as a relatively common manifestation of late Lyme disease in the United States. However, the original papers describing this entity had notable inconsistencies and certain inexplicable findings, such as reports that this condition developed in patients despite prior antibiotic treatment known to be highly effective for other manifestations of Lyme disease. More recent literature suggests that this entity is seen rarely, if at all. A chronic distal symmetric sensory neuropathy as a manifestation of late Lyme disease in North America should be regarded as controversial and in need of rigorous validation studies before acceptance as a documented clinical entity.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume87
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Borrelia burgdorferi
  • Lyme disease
  • Neuroborreliosis
  • Neuropathy
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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