A critical appraisal of "chronic lyme disease"

Henry M. Feder, Barbara J.B. Johnson, Susan O'Connell, Eugene D. Shapiro, Allen C. Steere, Gary P. Wormser, W. A. Agger, H. Artsob, P. Auwaerter, J. S. Dumler, J. S. Bakken, L. K. Bockenstedt, J. Green, R. J. Dattwyler, J. Munoz, R. B. Nadelman, I. Schwartz, T. Draper, E. McSweegan, J. J. HalperinM. S. Klempner, P. J. Krause, P. Mead, M. Morshed, R. Porwancher, J. D. Radolf, R. P. Smith, S. Sood, A. Weinstein, S. J. Wong, L. Zemel

Research output: Contribution to journalReview articlepeer-review

369 Scopus citations


"Chronic Lyme disease" is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.

Original languageEnglish (US)
Pages (from-to)1422
Number of pages1
JournalNew England Journal of Medicine
Issue number14
StatePublished - Oct 4 2007

ASJC Scopus subject areas

  • Medicine(all)


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