TY - JOUR
T1 - A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes
AU - Boorjian, Stephen A.
AU - Eastham, James A.
AU - Graefen, Markus
AU - Guillonneau, Bertrand
AU - Karnes, R. Jeffrey
AU - Moul, Judd W.
AU - Schaeffer, Edward M.
AU - Stief, Christian
AU - Zorn, Kevin C.
PY - 2012/4
Y1 - 2012/4
N2 - Context: The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective: Critically review published oncologic and functional outcomes after RP, and evaluate factors associated with these outcome measures. Evidence acquisition: A review of the literature was performed using the Medline and Web of Sciences databases. Relevant reports published between 1980 and 2011 identified using the keywords prostate cancer, radical prostatectomy, prostate-specific antigen, biochemical recurrence, incontinence, and erectile dysfunction were reviewed and summarized. Evidence synthesis: Cancer control rates following RP largely depend on the definition of treatment efficacy. While up to 40% of men have been reported to experience postoperative biochemical recurrence on long-term follow-up, death from prostate cancer has been noted in
AB - Context: The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective: Critically review published oncologic and functional outcomes after RP, and evaluate factors associated with these outcome measures. Evidence acquisition: A review of the literature was performed using the Medline and Web of Sciences databases. Relevant reports published between 1980 and 2011 identified using the keywords prostate cancer, radical prostatectomy, prostate-specific antigen, biochemical recurrence, incontinence, and erectile dysfunction were reviewed and summarized. Evidence synthesis: Cancer control rates following RP largely depend on the definition of treatment efficacy. While up to 40% of men have been reported to experience postoperative biochemical recurrence on long-term follow-up, death from prostate cancer has been noted in
KW - Biochemical recurrence
KW - Erectile dysfunction
KW - Incontinence
KW - Prostate cancer
KW - Prostate-specific antigen
KW - Radical prostatectomy
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U2 - 10.1016/j.eururo.2011.11.053
DO - 10.1016/j.eururo.2011.11.053
M3 - Article
C2 - 22169079
AN - SCOPUS:84857658304
SN - 0302-2838
VL - 61
SP - 664
EP - 675
JO - European Urology
JF - European Urology
IS - 4
ER -