A Critical Analysis of the Current Knowledge of Surgical Anatomy Related to Optimization of Cancer Control and Preservation of Continence and Erection in Candidates for Radical Prostatectomy

Jochen Walz, Arthur Burnett, Anthony J. Costello, James A. Eastham, Markus Graefen, Bertrand Guillonneau, Mani Menon, Francesco Montorsi, Robert P. Myers, Bernardo Rocco, Arnauld Villers

Research output: Contribution to journalArticle

Abstract

Context: Detailed knowledge of the anatomy of the prostate and adjacent tissues is mandatory during radical prostatectomy to ensure reliable oncologic and functional outcomes. Objective: To review critically and to summarize the available literature on surgical anatomy of the prostate and adjacent structures involved in cancer control, erectile function, and urinary continence. Evidence acquisition: A search of the PubMed database was performed using the keywords radical prostatectomy, anatomy, neurovascular bundle, fascia, pelvis, and sphincter. Relevant articles and textbook chapters were reviewed, analyzed, and summarized. Evidence synthesis: Anatomy of the prostate and the adjacent tissues varies substantially. The fascia surrounding the prostate is multilayered, sometimes either fused with the prostate capsule or clearly separated from the capsule as a reflection of interindividual variations. The neurovascular bundle (NVB) is situated between the fascial layers covering the prostate. The NVB is composed of numerous nerve fibers superimposed on a scaffold of veins, arteries, and variable amounts of adipose tissue surrounding almost the entire lateral and posterior surfaces of the prostate. The NVB is also in close, cage-like contact to the seminal vesicles. The external urethral sphincter is a complex structure in close anatomic and functional relationship to the pelvic floor, and its fragile innervation is in close association to the prostate apex. Finally, the shape and size of the prostate can significantly modify the anatomy of the NVB, the urethral sphincter, the dorsal vascular complex, and the pubovesical/puboprostatic ligaments. Conclusions: The surgical anatomy of the prostate and adjacent tissues involved in radical prostatectomy is complex. Precise knowledge of all relevant anatomic structures facilitates surgical orientation and dissection during radical prostatectomy and ideally translates into both superior rates of cancer control and improved functional outcomes postoperatively.

Original languageEnglish (US)
Pages (from-to)179-192
Number of pages14
JournalEuropean Urology
Volume57
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Prostatectomy
Prostate
Anatomy
Neoplasms
Fascia
Urethra
Capsules
Pelvic Floor
Textbooks
Seminal Vesicles
Pelvis
Nerve Fibers
Ligaments
PubMed
Blood Vessels
Adipose Tissue
Dissection
Veins
Arteries
Databases

Keywords

  • Anatomy
  • Erectile dysfunction
  • Neurovascular bundle
  • Penis
  • Prostate
  • Prostate cancer
  • Radical prostatectomy
  • Sphincter
  • Urethra
  • Urinary incontinence

ASJC Scopus subject areas

  • Urology

Cite this

A Critical Analysis of the Current Knowledge of Surgical Anatomy Related to Optimization of Cancer Control and Preservation of Continence and Erection in Candidates for Radical Prostatectomy. / Walz, Jochen; Burnett, Arthur; Costello, Anthony J.; Eastham, James A.; Graefen, Markus; Guillonneau, Bertrand; Menon, Mani; Montorsi, Francesco; Myers, Robert P.; Rocco, Bernardo; Villers, Arnauld.

In: European Urology, Vol. 57, No. 2, 02.2010, p. 179-192.

Research output: Contribution to journalArticle

Walz, Jochen ; Burnett, Arthur ; Costello, Anthony J. ; Eastham, James A. ; Graefen, Markus ; Guillonneau, Bertrand ; Menon, Mani ; Montorsi, Francesco ; Myers, Robert P. ; Rocco, Bernardo ; Villers, Arnauld. / A Critical Analysis of the Current Knowledge of Surgical Anatomy Related to Optimization of Cancer Control and Preservation of Continence and Erection in Candidates for Radical Prostatectomy. In: European Urology. 2010 ; Vol. 57, No. 2. pp. 179-192.
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abstract = "Context: Detailed knowledge of the anatomy of the prostate and adjacent tissues is mandatory during radical prostatectomy to ensure reliable oncologic and functional outcomes. Objective: To review critically and to summarize the available literature on surgical anatomy of the prostate and adjacent structures involved in cancer control, erectile function, and urinary continence. Evidence acquisition: A search of the PubMed database was performed using the keywords radical prostatectomy, anatomy, neurovascular bundle, fascia, pelvis, and sphincter. Relevant articles and textbook chapters were reviewed, analyzed, and summarized. Evidence synthesis: Anatomy of the prostate and the adjacent tissues varies substantially. The fascia surrounding the prostate is multilayered, sometimes either fused with the prostate capsule or clearly separated from the capsule as a reflection of interindividual variations. The neurovascular bundle (NVB) is situated between the fascial layers covering the prostate. The NVB is composed of numerous nerve fibers superimposed on a scaffold of veins, arteries, and variable amounts of adipose tissue surrounding almost the entire lateral and posterior surfaces of the prostate. The NVB is also in close, cage-like contact to the seminal vesicles. The external urethral sphincter is a complex structure in close anatomic and functional relationship to the pelvic floor, and its fragile innervation is in close association to the prostate apex. Finally, the shape and size of the prostate can significantly modify the anatomy of the NVB, the urethral sphincter, the dorsal vascular complex, and the pubovesical/puboprostatic ligaments. Conclusions: The surgical anatomy of the prostate and adjacent tissues involved in radical prostatectomy is complex. Precise knowledge of all relevant anatomic structures facilitates surgical orientation and dissection during radical prostatectomy and ideally translates into both superior rates of cancer control and improved functional outcomes postoperatively.",
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