A coupled chemo-fluidic computational model for thrombogenesis in infarcted left ventricles

Jung Hee Seo, Thura Abd, Richard T. George, Rajat Mittal

Research output: Contribution to journalArticlepeer-review

Abstract

A coupled chemo-fluidic computational model for investigating flow-mediated thrombogenesis in infarcted left ventricles (LVs) is pro-posed. LV thrombus (LVT) formation after the acute myocardial infarction (AMI) may lead to thromboembolic events that are associ-ated with high mortality and morbidity, and reliable stratification of LVT risk is the key to managing the treatment of AMI patients. There have been several studies emphasizing the importance of LV blood flow patterns on thrombus formation; however, given the complex interplay between ventricular flow dynamics and biochemistry of throm-bogenesis, current understanding is mostly empirical. In the present model, blood flow in the LV is obtained by solving the incompressible Navier-Stokes equations, and this is coupled to the biochemical modeling of the coagulation cascade, platelet activation, and fibrinogen polym-erization. The coupled model is used to examine the effect of ven-tricular flow patterns on thrombogenesis in modeled ventricles. It is expected that the method developed here will enable in-depth studies of thrombogenesis in patient-derived infarcted LV models.

Original languageEnglish (US)
Pages (from-to)H1567-H1582
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume310
Issue number11
DOIs
StatePublished - Jun 2016

Keywords

  • Biochemical reaction
  • Blood clot
  • Cardiac flow
  • Coagulation cascade
  • Computational hemodynamics
  • Intraventricular flow

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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