TY - JOUR
T1 - A cost-benefit analysis of preimplantation genetic diagnosis for carrier couples of cystic fibrosis
AU - Davis, Lynn B.
AU - Champion, Sara J.
AU - Fair, Steve O.
AU - Baker, Valerie L.
AU - Garber, Alan M.
N1 - Funding Information:
Supported by the Agency for Healthcare Research and Quality, training grant HS000028-21.
PY - 2010/4
Y1 - 2010/4
N2 - Objective: To perform a cost-benefit analysis of preimplantation genetic diagnosis (PGD) for carrier couples of cystic fibrosis (CF) compared with the alternative of natural conception (NC) followed by prenatal testing and termination of affected pregnancies. Design: Cost-benefit analysis using a decision analytic model. Setting: Outpatient reproductive health practices. Patient(s): A simulated cohort of 1,000 female patients. Intervention(s): We calculated the net benefit of giving birth to a child as the present value of lifetime earnings minus lifetime medical costs. Main Outcome Measure(s): Net benefits in dollars. Result(s): When used for women younger than 35 years of age, the net benefit of PGD over NC was $182,000 ($715,000 vs. $532,000, respectively). For women aged 35-40 years, the net benefit of PGD over NC was $114,000 ($634,000 vs. $520,000, respectively). For women older than 40 years, however, the net benefit of PGD over NC was -$148,000 ($302,000 vs. $450,000, respectively). Conclusion(s): Preimplantation genetic diagnosis provides net economic benefits when used by carrier couples of CF. Although there is an upper limit of maternal age at which economic benefit can be demonstrated, carrier couples of CF should be offered PGD for prevention of an affected child.
AB - Objective: To perform a cost-benefit analysis of preimplantation genetic diagnosis (PGD) for carrier couples of cystic fibrosis (CF) compared with the alternative of natural conception (NC) followed by prenatal testing and termination of affected pregnancies. Design: Cost-benefit analysis using a decision analytic model. Setting: Outpatient reproductive health practices. Patient(s): A simulated cohort of 1,000 female patients. Intervention(s): We calculated the net benefit of giving birth to a child as the present value of lifetime earnings minus lifetime medical costs. Main Outcome Measure(s): Net benefits in dollars. Result(s): When used for women younger than 35 years of age, the net benefit of PGD over NC was $182,000 ($715,000 vs. $532,000, respectively). For women aged 35-40 years, the net benefit of PGD over NC was $114,000 ($634,000 vs. $520,000, respectively). For women older than 40 years, however, the net benefit of PGD over NC was -$148,000 ($302,000 vs. $450,000, respectively). Conclusion(s): Preimplantation genetic diagnosis provides net economic benefits when used by carrier couples of CF. Although there is an upper limit of maternal age at which economic benefit can be demonstrated, carrier couples of CF should be offered PGD for prevention of an affected child.
KW - Preimplantation genetic diagnosis
KW - carrier
KW - cost-benefit analysis
KW - cystic fibrosis
KW - preimplantation genetic screening
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U2 - 10.1016/j.fertnstert.2008.12.053
DO - 10.1016/j.fertnstert.2008.12.053
M3 - Article
C2 - 19439290
AN - SCOPUS:77949913431
SN - 0015-0282
VL - 93
SP - 1793
EP - 1804
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -