A cost-benefit analysis of preimplantation genetic diagnosis for carrier couples of cystic fibrosis

Lynn B. Davis, Sara J. Champion, Steve O. Fair, Valerie L. Baker, Alan M. Garber

Research output: Contribution to journalArticle

Abstract

Objective: To perform a cost-benefit analysis of preimplantation genetic diagnosis (PGD) for carrier couples of cystic fibrosis (CF) compared with the alternative of natural conception (NC) followed by prenatal testing and termination of affected pregnancies. Design: Cost-benefit analysis using a decision analytic model. Setting: Outpatient reproductive health practices. Patient(s): A simulated cohort of 1,000 female patients. Intervention(s): We calculated the net benefit of giving birth to a child as the present value of lifetime earnings minus lifetime medical costs. Main Outcome Measure(s): Net benefits in dollars. Result(s): When used for women younger than 35 years of age, the net benefit of PGD over NC was $182,000 ($715,000 vs. $532,000, respectively). For women aged 35-40 years, the net benefit of PGD over NC was $114,000 ($634,000 vs. $520,000, respectively). For women older than 40 years, however, the net benefit of PGD over NC was -$148,000 ($302,000 vs. $450,000, respectively). Conclusion(s): Preimplantation genetic diagnosis provides net economic benefits when used by carrier couples of CF. Although there is an upper limit of maternal age at which economic benefit can be demonstrated, carrier couples of CF should be offered PGD for prevention of an affected child.

Original languageEnglish (US)
Pages (from-to)1793-1804
Number of pages12
JournalFertility and sterility
Volume93
Issue number6
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Keywords

  • Preimplantation genetic diagnosis
  • carrier
  • cost-benefit analysis
  • cystic fibrosis
  • preimplantation genetic screening

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'A cost-benefit analysis of preimplantation genetic diagnosis for carrier couples of cystic fibrosis'. Together they form a unique fingerprint.

  • Cite this