TY - JOUR
T1 - A correspondence analysis revealed frailty deficits aggregate and are multidimensional
AU - Sourial, Nadia
AU - Wolfson, Christina
AU - Bergman, Howard
AU - Zhu, Bin
AU - Karunananthan, Sathya
AU - Quail, Jacqueline
AU - Fletcher, John
AU - Weiss, Deborah
AU - Bandeen-Roche, Karen
AU - Béland, François
N1 - Funding Information:
The authors are grateful to Dr. Russell Steele for his statistical expertise in MI. Sources of funding include the Solidage Research Group and Dr. Joseph Kaufmann Chair in Geriatric Medicine, McGill University ; Canadian Initiative on Frailty and Aging ; Canadian Institutes of Health Research (CIHR) International Opportunity Program Development Grant 68739 ; CIHR team grant in frailty and aging 82945; and Johns Hopkins Older Americans Independence Center (National Institutes of Health award P50AG-021334-01).
PY - 2010/6
Y1 - 2010/6
N2 - Objective: To examine the relationships among seven frailty domains: nutrition, physical activity, mobility, strength, energy, cognition, and mood, using data from three studies. Study Design and Setting: Data from three studies were separately analyzed using multiple correspondence analysis (MCA). The graphical output of MCA was used to assess (1) if the presence of deficits in the frailty domains separate from the absence of deficits on the graph, (2) the dimensionality of the domains, (3) the clustering of domains within each dimension, and (4) their relationship with age, sex, and disability. Results were compared across the studies. Results: In two studies, presence of deficits for all domains separated from absence of deficits. In the third study, there was separation in all domains except cognition. Three main dimensions were retained in each study; however, assigned dimensionality of domains differed. The clustering of mobility with energy and/or strength was consistent across studies. Deficits were associated with older age, female sex, and disability. Conclusion: Our results suggest that frailty is a multidimensional concept for which the relationships among domains differ according to the population characteristics. These domains, with the possible exception of cognition, appear to aggregate together and share a common underlying construct.
AB - Objective: To examine the relationships among seven frailty domains: nutrition, physical activity, mobility, strength, energy, cognition, and mood, using data from three studies. Study Design and Setting: Data from three studies were separately analyzed using multiple correspondence analysis (MCA). The graphical output of MCA was used to assess (1) if the presence of deficits in the frailty domains separate from the absence of deficits on the graph, (2) the dimensionality of the domains, (3) the clustering of domains within each dimension, and (4) their relationship with age, sex, and disability. Results were compared across the studies. Results: In two studies, presence of deficits for all domains separated from absence of deficits. In the third study, there was separation in all domains except cognition. Three main dimensions were retained in each study; however, assigned dimensionality of domains differed. The clustering of mobility with energy and/or strength was consistent across studies. Deficits were associated with older age, female sex, and disability. Conclusion: Our results suggest that frailty is a multidimensional concept for which the relationships among domains differ according to the population characteristics. These domains, with the possible exception of cognition, appear to aggregate together and share a common underlying construct.
KW - Association
KW - Domains of frailty
KW - Epidemiology
KW - Frailty
KW - Multiple correspondence analysis
KW - Older persons
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U2 - 10.1016/j.jclinepi.2009.08.007
DO - 10.1016/j.jclinepi.2009.08.007
M3 - Article
C2 - 19880286
AN - SCOPUS:77956622162
SN - 0895-4356
VL - 63
SP - 647
EP - 654
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 6
ER -