A cooperative interaction of human T-cell leukemia virus type 1 Tax with the p21 cyclin-dependent kinase inhibitor activates the human immunodeficiency virus type 1 enhancer

Scott F. Parker, Neil D. Perkins, Scott D. Gitlin, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

Interactions between the Tax transactivator of human T-cell leukemia virus type 1 (HTLV-1) and a cell cycle regulatory protein have been examined. We report cooperative stimulation of human immunodeficiency virus type 1 gene expression by Tax and a regulator of cell cycle progression, the p21 cyclin-dependent kinase inhibitor (CKI). This cooperativity results from the effect of p21 on transcriptional coactivation by Tax-induced NF-κB. This effect was abrogated by a mutation in Tax which specifically eliminated NF-κB induction, was inhibitable by IκB-α, and was markedly reduced in human immunodeficiency virus reporter plasmids with mutant κB sites. These studies demonstrate that transcriptional activation by Tax is influenced by cell cycle regulatory proteins.

Original languageEnglish (US)
Pages (from-to)5731-5734
Number of pages4
JournalJournal of Virology
Volume70
Issue number8
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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