Interactions between the Tax transactivator of human T-cell leukemia virus type 1 (HTLV-1) and a cell cycle regulatory protein have been examined. We report cooperative stimulation of human immunodeficiency virus type 1 gene expression by Tax and a regulator of cell cycle progression, the p21 cyclin-dependent kinase inhibitor (CKI). This cooperativity results from the effect of p21 on transcriptional coactivation by Tax-induced NF-κB. This effect was abrogated by a mutation in Tax which specifically eliminated NF-κB induction, was inhibitable by IκB-α, and was markedly reduced in human immunodeficiency virus reporter plasmids with mutant κB sites. These studies demonstrate that transcriptional activation by Tax is influenced by cell cycle regulatory proteins.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Virology|
|State||Published - Aug 1996|
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