TY - JOUR
T1 - A Controlled Trial of Buprenorphine Treatment for Opioid Dependence
AU - Johnson, Rolley E.
AU - Jaffe, Jerome H.
AU - Fudala, Paul J.
PY - 1992/5/27
Y1 - 1992/5/27
N2 - Objective. —To assess the efficacy of buprenorphine for short-term maintenance/detoxification. Design. —A randomized, double-blind, parallel group study comparing buprenorphine, 8 mg/d, methadone, 60 mg/d, and methadone, 20 mg/d, in a 17-week maintenance phase followed by an 8-week detoxification phase. Setting. —Outpatient facilities at the Addiction Research Center, Baltimore, Md. Patients. —One hundred sixty-two volunteers seeking treatment for opioid dependence. Intervention. —In addition to the medication, counseling using a relapse prevention model was offered but not required. Primary Outcome Measures. —Retention time in treatment, urine samples negative for opioids, and failure to maintain abstinence. Results. —Throughout the maintenance phase, retention rates were significantly greater for buprenorphine (42%) than for methadone, 20 mg/d (20%, P
AB - Objective. —To assess the efficacy of buprenorphine for short-term maintenance/detoxification. Design. —A randomized, double-blind, parallel group study comparing buprenorphine, 8 mg/d, methadone, 60 mg/d, and methadone, 20 mg/d, in a 17-week maintenance phase followed by an 8-week detoxification phase. Setting. —Outpatient facilities at the Addiction Research Center, Baltimore, Md. Patients. —One hundred sixty-two volunteers seeking treatment for opioid dependence. Intervention. —In addition to the medication, counseling using a relapse prevention model was offered but not required. Primary Outcome Measures. —Retention time in treatment, urine samples negative for opioids, and failure to maintain abstinence. Results. —Throughout the maintenance phase, retention rates were significantly greater for buprenorphine (42%) than for methadone, 20 mg/d (20%, P
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U2 - 10.1001/jama.1992.03480200058024
DO - 10.1001/jama.1992.03480200058024
M3 - Article
C2 - 1578593
AN - SCOPUS:0026539226
SN - 0098-7484
VL - 267
SP - 2750
EP - 2755
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 20
ER -