A Controlled Trial of Buprenorphine Treatment for Opioid Dependence

Rolley E. Johnson, Jerome H. Jaffe, Paul J. Fudala

Research output: Contribution to journalArticlepeer-review

472 Scopus citations


Objective. —To assess the efficacy of buprenorphine for short-term maintenance/detoxification. Design. —A randomized, double-blind, parallel group study comparing buprenorphine, 8 mg/d, methadone, 60 mg/d, and methadone, 20 mg/d, in a 17-week maintenance phase followed by an 8-week detoxification phase. Setting. —Outpatient facilities at the Addiction Research Center, Baltimore, Md. Patients. —One hundred sixty-two volunteers seeking treatment for opioid dependence. Intervention. —In addition to the medication, counseling using a relapse prevention model was offered but not required. Primary Outcome Measures. —Retention time in treatment, urine samples negative for opioids, and failure to maintain abstinence. Results. —Throughout the maintenance phase, retention rates were significantly greater for buprenorphine (42%) than for methadone, 20 mg/d (20%, P

Original languageEnglish (US)
Pages (from-to)2750-2755
Number of pages6
JournalJournal of the American Medical Association
Issue number20
StatePublished - May 27 1992

ASJC Scopus subject areas

  • Medicine(all)


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