A controlled comparison of buprenorphine and clonidine for acute detoxification from opioids

Lawrence J Cheskin; Paul J. Fudala; Rolley E. Johnson

doi:10.1016/0376-8716(94)90093-0

A controlled comparison of buprenorphine and clonidine for acute detoxification from opioids

Lawrence J Cheskin, Paul J. Fudala, Rolley E. Johnson

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

We compared the short-term efficacy of a high-dose, 3 day regimen of buprenorphine to a standard 5-day course of clonidine in attenuating the signs and symptoms of the acute opioid abstinence syndrome during rapid detoxification from heroin in 25 men and women admitted to a closed inpatient research ward for this randomized, double-blind, parallel-group trial. Among the 18 completers, there were no significant differences between the buprenorphine and clonidine groups on five subjective and six physiological measures. However, clonidine lowered blood pressure and buprenorphine provided more effective early relief of withdrawal symptoms.

Original language	English (US)
Pages (from-to)	115-121
Number of pages	7
Journal	Drug and Alcohol Dependence
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/0376-8716(94)90093-0
State	Published - 1994

Keywords

Buprenorphine
Clonidine
Controlled trial
Detoxification
Opioid

ASJC Scopus subject areas

General Medicine
Behavioral Neuroscience
Toxicology
Health(social science)

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10.1016/0376-8716(94)90093-0

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A controlled comparison of buprenorphine and clonidine for acute detoxification from opioids

Abstract

Keywords

ASJC Scopus subject areas

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