A Continuing Controversy: Magnesium Sulfate in the Treatment of Eclamptic Seizures

Peter W Kaplan, Ronald P Lesser, Robert S. Fisher, John T. Repke, Daniel F Hanley

Research output: Contribution to journalArticle

Abstract

We would like to address some of the issues raised by Pritchard1 and Lindheimer2 in their letters to the editor. Pritchard outlines a plan of treatment for eclampsia that includes parenteral magnesium sulfate, intravenous hydralazine, and the delivery of the baby; he is concerned that a proposal for a different treatment regimen for eclampsia would not be approved by a human subjects committee given the apparently satisfactory results of his treatment protocol. In his experience, magnesium sulfate “almost always stops convulsions promptly and prevents their recurrence,” and he comments on the effect of magnesium sulfate: “some [believe] that it is not an anticonvulsant, presumably because the arrest of the convulsions and the prevention of their recurrence does not induce generalized central nervous system depression in mother or fetus.” We wish to note, parenthetically, that an intrinsic property of anticonvulsant medication is not the induction of “generalized central nervous.

Original languageEnglish (US)
Pages (from-to)1031-1032
Number of pages2
JournalArchives of Neurology
Volume47
Issue number9
DOIs
StatePublished - 1990

Fingerprint

Magnesium Sulfate
Eclampsia
Seizures
Anticonvulsants
Recurrence
Hydralazine
Clinical Protocols
Fetus
Therapeutics
Central Nervous System
Magnesium

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

A Continuing Controversy : Magnesium Sulfate in the Treatment of Eclamptic Seizures. / Kaplan, Peter W; Lesser, Ronald P; Fisher, Robert S.; Repke, John T.; Hanley, Daniel F.

In: Archives of Neurology, Vol. 47, No. 9, 1990, p. 1031-1032.

Research output: Contribution to journalArticle

@article{4f7f980e55794ea0941522ed959050ca,
title = "A Continuing Controversy: Magnesium Sulfate in the Treatment of Eclamptic Seizures",
abstract = "We would like to address some of the issues raised by Pritchard1 and Lindheimer2 in their letters to the editor. Pritchard outlines a plan of treatment for eclampsia that includes parenteral magnesium sulfate, intravenous hydralazine, and the delivery of the baby; he is concerned that a proposal for a different treatment regimen for eclampsia would not be approved by a human subjects committee given the apparently satisfactory results of his treatment protocol. In his experience, magnesium sulfate “almost always stops convulsions promptly and prevents their recurrence,” and he comments on the effect of magnesium sulfate: “some [believe] that it is not an anticonvulsant, presumably because the arrest of the convulsions and the prevention of their recurrence does not induce generalized central nervous system depression in mother or fetus.” We wish to note, parenthetically, that an intrinsic property of anticonvulsant medication is not the induction of “generalized central nervous.",
author = "Kaplan, {Peter W} and Lesser, {Ronald P} and Fisher, {Robert S.} and Repke, {John T.} and Hanley, {Daniel F}",
year = "1990",
doi = "10.1001/archneur.1990.00530090111021",
language = "English (US)",
volume = "47",
pages = "1031--1032",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "9",

}

TY - JOUR

T1 - A Continuing Controversy

T2 - Magnesium Sulfate in the Treatment of Eclamptic Seizures

AU - Kaplan, Peter W

AU - Lesser, Ronald P

AU - Fisher, Robert S.

AU - Repke, John T.

AU - Hanley, Daniel F

PY - 1990

Y1 - 1990

N2 - We would like to address some of the issues raised by Pritchard1 and Lindheimer2 in their letters to the editor. Pritchard outlines a plan of treatment for eclampsia that includes parenteral magnesium sulfate, intravenous hydralazine, and the delivery of the baby; he is concerned that a proposal for a different treatment regimen for eclampsia would not be approved by a human subjects committee given the apparently satisfactory results of his treatment protocol. In his experience, magnesium sulfate “almost always stops convulsions promptly and prevents their recurrence,” and he comments on the effect of magnesium sulfate: “some [believe] that it is not an anticonvulsant, presumably because the arrest of the convulsions and the prevention of their recurrence does not induce generalized central nervous system depression in mother or fetus.” We wish to note, parenthetically, that an intrinsic property of anticonvulsant medication is not the induction of “generalized central nervous.

AB - We would like to address some of the issues raised by Pritchard1 and Lindheimer2 in their letters to the editor. Pritchard outlines a plan of treatment for eclampsia that includes parenteral magnesium sulfate, intravenous hydralazine, and the delivery of the baby; he is concerned that a proposal for a different treatment regimen for eclampsia would not be approved by a human subjects committee given the apparently satisfactory results of his treatment protocol. In his experience, magnesium sulfate “almost always stops convulsions promptly and prevents their recurrence,” and he comments on the effect of magnesium sulfate: “some [believe] that it is not an anticonvulsant, presumably because the arrest of the convulsions and the prevention of their recurrence does not induce generalized central nervous system depression in mother or fetus.” We wish to note, parenthetically, that an intrinsic property of anticonvulsant medication is not the induction of “generalized central nervous.

UR - http://www.scopus.com/inward/record.url?scp=0025078203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025078203&partnerID=8YFLogxK

U2 - 10.1001/archneur.1990.00530090111021

DO - 10.1001/archneur.1990.00530090111021

M3 - Article

C2 - 2204330

AN - SCOPUS:0025078203

VL - 47

SP - 1031

EP - 1032

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 9

ER -