A contemporary review of indications for primary surgical care of patients with squamous cell carcinoma of the head and neck

Christine G. Gourin, Jonas T. Johnson

Research output: Contribution to journalReview articlepeer-review

Abstract

The success of organ preservation protocols in laryngeal cancer has led to an increase in the use of primary chemoradiation in both laryngeal and extralaryngeal sites, despite a paucity of randomized controlled clinical trial data comparing nonoperative treatment to the gold standard of surgery followed by postoperative radiation for adverse pathologic features for head and neck cancer, and an increasing recognition that the high surgical salvage rates enjoyed by laryngeal cancer patients do not translate to extralaryngeal sites. These data suggest that there is a need to apply more rigorous standards to the use of organ preservation strategies and offer an opportunity to review the role of primary surgery in head and neck cancer.

Original languageEnglish (US)
Pages (from-to)2124-2134
Number of pages11
JournalLaryngoscope
Volume119
Issue number11
DOIs
StatePublished - Nov 1 2009

Keywords

  • Chemoradiation
  • Head and neck neoplasms
  • Hypopharynx
  • Larynx
  • Oral cavity
  • Oropharynx
  • Radiation
  • Squamous cell cancer
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

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