A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

S. Duckett Colin; Victor E. Nava; Richard W. Gedrich; Rollie J. Clem; Jennifer L. Van Dongen; Molly C. Gilfillan; Helena Shiels; J. Marie Hardwick; Craig B. Thompson

doi:10.1002/j.1460-2075.1996.tb00629.x

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

S. Duckett Colin, Victor E. Nava, Richard W. Gedrich, Rollie J. Clem, Jennifer L. Van Dongen, Molly C. Gilfillan, Helena Shiels, J. Marie Hardwick, Craig B. Thompson

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

507 Scopus citations

Abstract

The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells. The ability of iap to regulate programmed cell death in widely divergent species raised the possibility that cellular homologs of iap might exist. Consistent with this hypothesis, we have isolated Drosophila and human genes which encode IAP-like proteins (dILP and hILP). Like IAP, both dILP and hILP contain amino-terminal baculovirus IAP repeats (BIRs) and carboxy-terminal RING finger domains. Human ilp encodes a widely expressed cytoplasmic protein that can suppress apoptosis in transfected cells. An analysis of the expressed sequence tag database suggests that hilp is one of several human genes related to iap. Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis.

Original language	English (US)
Pages (from-to)	2685-2694
Number of pages	10
Journal	EMBO Journal
Volume	15
Issue number	11
DOIs	https://doi.org/10.1002/j.1460-2075.1996.tb00629.x
State	Published - 1996

Keywords

Apoptosis
Molecular cloning
Programmed cell death
Viruses
iap

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.1002/j.1460-2075.1996.tb00629.x

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title = "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors",

abstract = "The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells. The ability of iap to regulate programmed cell death in widely divergent species raised the possibility that cellular homologs of iap might exist. Consistent with this hypothesis, we have isolated Drosophila and human genes which encode IAP-like proteins (dILP and hILP). Like IAP, both dILP and hILP contain amino-terminal baculovirus IAP repeats (BIRs) and carboxy-terminal RING finger domains. Human ilp encodes a widely expressed cytoplasmic protein that can suppress apoptosis in transfected cells. An analysis of the expressed sequence tag database suggests that hilp is one of several human genes related to iap. Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis.",

keywords = "Apoptosis, Molecular cloning, Programmed cell death, Viruses, iap",

author = "Colin, {S. Duckett} and Nava, {Victor E.} and Gedrich, {Richard W.} and Clem, {Rollie J.} and {Van Dongen}, {Jennifer L.} and Gilfillan, {Molly C.} and Helena Shiels and Hardwick, {J. Marie} and Thompson, {Craig B.}",

year = "1996",

doi = "10.1002/j.1460-2075.1996.tb00629.x",

language = "English (US)",

volume = "15",

pages = "2685--2694",

journal = "EMBO Journal",

issn = "0261-4189",

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T1 - A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

AU - Colin, S. Duckett

AU - Nava, Victor E.

AU - Gedrich, Richard W.

AU - Clem, Rollie J.

AU - Van Dongen, Jennifer L.

AU - Gilfillan, Molly C.

AU - Shiels, Helena

AU - Hardwick, J. Marie

AU - Thompson, Craig B.

PY - 1996

Y1 - 1996

N2 - The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells. The ability of iap to regulate programmed cell death in widely divergent species raised the possibility that cellular homologs of iap might exist. Consistent with this hypothesis, we have isolated Drosophila and human genes which encode IAP-like proteins (dILP and hILP). Like IAP, both dILP and hILP contain amino-terminal baculovirus IAP repeats (BIRs) and carboxy-terminal RING finger domains. Human ilp encodes a widely expressed cytoplasmic protein that can suppress apoptosis in transfected cells. An analysis of the expressed sequence tag database suggests that hilp is one of several human genes related to iap. Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis.

AB - The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells. The ability of iap to regulate programmed cell death in widely divergent species raised the possibility that cellular homologs of iap might exist. Consistent with this hypothesis, we have isolated Drosophila and human genes which encode IAP-like proteins (dILP and hILP). Like IAP, both dILP and hILP contain amino-terminal baculovirus IAP repeats (BIRs) and carboxy-terminal RING finger domains. Human ilp encodes a widely expressed cytoplasmic protein that can suppress apoptosis in transfected cells. An analysis of the expressed sequence tag database suggests that hilp is one of several human genes related to iap. Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis.

KW - Apoptosis

KW - Molecular cloning

KW - Programmed cell death

KW - Viruses

KW - iap

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DO - 10.1002/j.1460-2075.1996.tb00629.x

M3 - Article

C2 - 8654366

AN - SCOPUS:15844425961

SN - 0261-4189

VL - 15

SP - 2685

EP - 2694

JO - EMBO Journal

JF - EMBO Journal

IS - 11

ER -

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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