A condition variation study for radioiodination via triazene intermediates

N. I. Foster, Robert F Dannals, H. D. Burns, N. D. Heindel

Research output: Contribution to journalArticle

Abstract

Pyrrolidyl triazenes prepared by interception of the diazonium transient in the Sandmeyer reaction of amines can serve as useful intermediates in the iodination and radioiodination of aryl rings. Decomposition of such triazenes in the presence of iodide is acid-catalyzed and is sensitive to choice of solvent, acid, and triazene structure. A condition variation study by HPLC of four different solvent systems and two non-nucleophilic acids was carried out on the123I iodination of the triazenes of p-nitroaniline, p-anisidine and p-toluidine. This method has proven useful in radiolabeling of two pharmaceutical analogs which were not amenable to labeling through the classic Sandmeyer method.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalJournal of Radioanalytical Chemistry
Volume65
Issue number1-2
DOIs
StatePublished - Mar 1981

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Triazenes
Halogenation
Acids
Iodides
Amines
High Pressure Liquid Chromatography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Molecular Medicine

Cite this

A condition variation study for radioiodination via triazene intermediates. / Foster, N. I.; Dannals, Robert F; Burns, H. D.; Heindel, N. D.

In: Journal of Radioanalytical Chemistry, Vol. 65, No. 1-2, 03.1981, p. 95-105.

Research output: Contribution to journalArticle

Foster, N. I. ; Dannals, Robert F ; Burns, H. D. ; Heindel, N. D. / A condition variation study for radioiodination via triazene intermediates. In: Journal of Radioanalytical Chemistry. 1981 ; Vol. 65, No. 1-2. pp. 95-105.
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