A computer program for aligning a cDNA sequence with a genomic DNA sequence

Liliana Florea; George Hartzell; Zheng Zhang; Gerald M. Rubin; Webb Miller

doi:10.1101/gr.8.9.967

A computer program for aligning a cDNA sequence with a genomic DNA sequence

Liliana Florea, George Hartzell, Zheng Zhang, Gerald M. Rubin, Webb Miller

Research output: Contribution to journal › Article › peer-review

576 Scopus citations

Abstract

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

Original language	English (US)
Pages (from-to)	967-974
Number of pages	8
Journal	Genome research
Volume	8
Issue number	9
DOIs	https://doi.org/10.1101/gr.8.9.967
State	Published - Sep 1998
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1101/gr.8.9.967

Cite this

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title = "A computer program for aligning a cDNA sequence with a genomic DNA sequence",

abstract = "We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.",

author = "Liliana Florea and George Hartzell and Zheng Zhang and Rubin, {Gerald M.} and Webb Miller",

year = "1998",

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AU - Rubin, Gerald M.

AU - Miller, Webb

PY - 1998/9

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AB - We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

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A computer program for aligning a cDNA sequence with a genomic DNA sequence

Abstract

ASJC Scopus subject areas

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