A computer program for aligning a cDNA sequence with a genomic DNA sequence

Liliana Florea, George Hartzell, Zheng Zhang, Gerald M. Rubin, Webb Miller

Research output: Contribution to journalArticlepeer-review

Abstract

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

Original languageEnglish (US)
Pages (from-to)967-974
Number of pages8
JournalGenome research
Volume8
Issue number9
DOIs
StatePublished - Sep 1998
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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