A comprehensive review of risk factor, mechanism, and management of left ventricular assist device-associated stroke

Sung Min Cho, Pouya Tahsili-Fahadan, Ahmet Kilic, Chunwoo Choi, Randall C. Starling, Ken Uchino

Research output: Contribution to journalArticlepeer-review

Abstract

The use of left ventricular assist devices (LVADs) has been increasing in the last decade, along with the number of patients with advanced heart failure refractory to medical therapy. Ischemic stroke and intracranial hemorrhage remain the leading causes of morbidity and mortality in LVAD patients. Despite the common occurrence and the significant outcome impact, underlying mechanisms and management strategies of stroke in LVAD patients are controversial. In this article, we review our current knowledge on pathophysiology and risk factors of LVAD-associated stroke, outline the diagnostic approach, and discuss treatment strategies.

Original languageEnglish (US)
JournalSeminars in neurology
DOIs
StateAccepted/In press - 2021

Keywords

  • Heart failure
  • Intracranial hemorrhage
  • Ischemic stroke
  • Left ventricular assist device

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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