A comprehensive guide to the ROMK potassium channel: Form and function in health and disease

Paul A. Welling; Kevin Ho

doi:10.1152/ajprenal.00181.2009

A comprehensive guide to the ROMK potassium channel: Form and function in health and disease

Paul A. Welling, Kevin Ho

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Abstract

The discovery of the renal outer medullary K⁺ channel (ROMK, K_ir1.1), the founding member of the inward-rectifying K⁺ channel (K_ir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

Original language	English (US)
Pages (from-to)	F849-F863
Journal	American Journal of Physiology - Renal Physiology
Volume	297
Issue number	4
DOIs	https://doi.org/10.1152/ajprenal.00181.2009
State	Published - Oct 2009
Externally published	Yes

Keywords

Bartter's syndrome
Inward-rectifying potassium channel
K1.1
KCNJ
Phosphatidylinositol 4,5-bisphosphate
Pseudohypoaldosteronism type II
Serine- and glucocorticoid-regulated kinase-1
WNK kinase

ASJC Scopus subject areas

Physiology
Urology

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10.1152/ajprenal.00181.2009

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title = "A comprehensive guide to the ROMK potassium channel: Form and function in health and disease",

abstract = "The discovery of the renal outer medullary K+ channel (ROMK, Kir1.1), the founding member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.",

keywords = "Bartter's syndrome, Inward-rectifying potassium channel, K1.1, KCNJ, Phosphatidylinositol 4,5-bisphosphate, Pseudohypoaldosteronism type II, Serine- and glucocorticoid-regulated kinase-1, WNK kinase",

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AU - Welling, Paul A.

AU - Ho, Kevin

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N2 - The discovery of the renal outer medullary K+ channel (ROMK, Kir1.1), the founding member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

AB - The discovery of the renal outer medullary K+ channel (ROMK, Kir1.1), the founding member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

KW - Bartter's syndrome

KW - Inward-rectifying potassium channel

KW - K1.1

KW - KCNJ

KW - Phosphatidylinositol 4,5-bisphosphate

KW - Pseudohypoaldosteronism type II

KW - Serine- and glucocorticoid-regulated kinase-1

KW - WNK kinase

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DO - 10.1152/ajprenal.00181.2009

M3 - Review article

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SP - F849-F863

JO - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

IS - 4

ER -

A comprehensive guide to the ROMK potassium channel: Form and function in health and disease

Abstract

Keywords

ASJC Scopus subject areas

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