A comprehensive guide to the ROMK potassium channel: Form and function in health and disease

Paul A. Welling, Kevin Ho

Research output: Contribution to journalReview article

Abstract

The discovery of the renal outer medullary K+ channel (ROMK, Kir1.1), the founding member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

Original languageEnglish (US)
Pages (from-to)F849-F863
JournalAmerican Journal of Physiology - Renal Physiology
Volume297
Issue number4
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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Keywords

  • Bartter's syndrome
  • Inward-rectifying potassium channel
  • K1.1
  • KCNJ
  • Phosphatidylinositol 4,5-bisphosphate
  • Pseudohypoaldosteronism type II
  • Serine- and glucocorticoid-regulated kinase-1
  • WNK kinase

ASJC Scopus subject areas

  • Physiology
  • Urology

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