A Comprehensive Curated Reaction Map of Leptin Signaling Pathway

Vishalakshi Nanjappa, Rajesh Raju, Babylakshmi Muthusamy, Jyoti Sharma, Joji Kurian Thomas, Pachakkil A H Haridas Nidhina, H. C. Harsha, Akhilesh Pandey, Gopalakrishnapillai Anilkumar, T. S. Keshava Prasad

Research output: Contribution to journalArticlepeer-review

Abstract

Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalJournal of Proteomics and Bioinformatics
Volume4
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Adipocyte
  • Cytokine
  • Energy homeostasis
  • Leptin resistance
  • NetSlim
  • PathVisio

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Computer Science Applications

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