A comprehensive analysis of complex traits in Problem 2A

S. H. Juo, T. H. Beaty, D. L. Duffy, N. E. Maestri, V. L. Prenger, J. Zeiger, H. H. Lei, J. Coresh

Research output: Contribution to journalArticlepeer-review

Abstract

We used descriptive analysis to investigate the relationship between affection status and five quantitative traits (Q1-Q5) in Problem 2A and results suggested the five quantitative traits fall into two groups. The first group comprised three strongly correlated traits, Q1-Q3, which underlie affection status, and the second group comprised Q4 and Q5, which are not directly related to affection status. Segregation and linkage analyses of traits Q1-Q3 and affection status from the first replicate detected one of the major loci for Q1 (MG1) linked to marker 14 on chromosome 5 (D5G14). Because our segregation analysis failed to show evidence of a major locus effect on Q2, and we overlooked the interaction between MG3 and sex, we did not detect either MG2 or MG3. Using Haseman-Elston sib-pair analysis [Haseman and Elston, 1972], we also examined the statistical power of Q1 and type I error rate (using the environmental factor as an index), for the remaining 199 replicates in the context of a genome screen.

Original languageEnglish (US)
Pages (from-to)815-820
Number of pages6
JournalGenetic epidemiology
Volume14
Issue number6
DOIs
StatePublished - 1997

Keywords

  • Lod-score analysis
  • Segregation analysis
  • Sib-pair analysis

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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