Abstract
We used descriptive analysis to investigate the relationship between affection status and five quantitative traits (Q1-Q5) in Problem 2A and results suggested the five quantitative traits fall into two groups. The first group comprised three strongly correlated traits, Q1-Q3, which underlie affection status, and the second group comprised Q4 and Q5, which are not directly related to affection status. Segregation and linkage analyses of traits Q1-Q3 and affection status from the first replicate detected one of the major loci for Q1 (MG1) linked to marker 14 on chromosome 5 (D5G14). Because our segregation analysis failed to show evidence of a major locus effect on Q2, and we overlooked the interaction between MG3 and sex, we did not detect either MG2 or MG3. Using Haseman-Elston sib-pair analysis [Haseman and Elston, 1972], we also examined the statistical power of Q1 and type I error rate (using the environmental factor as an index), for the remaining 199 replicates in the context of a genome screen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 815-820 |
| Number of pages | 6 |
| Journal | Genetic epidemiology |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1997 |
Keywords
- Lod-score analysis
- Segregation analysis
- Sib-pair analysis
ASJC Scopus subject areas
- Epidemiology
- Genetics(clinical)