A comparison of Xenon-133 and Xenon-127 for the determination of regional cerebral blood flow measured by dynamic SPECT

R. Coppola, S. Marenco, D. W. Jones, K. F. Berman, D. R. Weinberger

Research output: Contribution to journalArticlepeer-review

Abstract

Phantom studies and cerebral blood flow (CBF) measurements in 11 normal subjects at rest were performed by single photon emission tomography (SPECT) with Xe-133 (16 mm full-width at half-maximum [FWHM] collimation) and Xe-127 (16 mm, 12 mm, and 9 mm FWHM collimation). The phantom results clearly illustrated the feasibility of Xe-127 studies and the advantage of Xe-127 over Xe-133 for equivalent patient dose exposures. CBF values obtained with Xe-127 were comparable to those of Xe-133 for the 16 mm collimator, although higher flow values were found with the better resolution, probably because of reduced partial volume effects. The correlations between the various groups of examinations were high, except for the Xe-133 and Xe-127 16 mm collimator groups. Xe-127 allows a considerable increase in the resolution of the images, while exposing the patient to a lower radiation dose. Potential limitations because of higher energy penetrating photons from Xe-127 were not observed in this specially shielded equipment.

Original languageEnglish (US)
Pages (from-to)187-200
Number of pages14
JournalPsychiatry Research - Neuroimaging
Volume45
Issue number3
StatePublished - Dec 1 1992
Externally publishedYes

Keywords

  • Increased resolution
  • Isotopes
  • Perfusion
  • Phantom studies
  • Radiotracer
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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