A comparison of type 2 diabetes outcomes among persons with and without severe mental illnesses

Lisa B. Dixon, Julie A. Kreyenbuhl, Faith B. Dickerson, Thomas W. Donner, Clayton H. Brown, Karen Wolheiter, Leticia Postrado, Richard W. Goldberg, Lijuan Fang, Christopher Mark Marano, Erick Messias

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Objective: Type 2 diabetes is an important comorbid medical condition associated with schizophrenia. The objective of this study was to compare glycosylated hemoglobin (HbA 1c) levels of patients who had type 2 diabetes and schizophrenia with those of patients who had type 2 diabetes and major mood disorders and those who had type 2 diabetes but who did not have severe mental illness. Methods: A sample of 300 patients with type 2 diabetes was recruited from community mental health centers in the greater Baltimore region and nearby primary care clinics. Of these, 100 had schizophrenia, 101 had a major mood disorder, and 99 had no identified severe mental illness. HbA 1c, the main outcome measure, was compared between the group with schizophrenia and the other two groups. Results: All three groups had HbA 1c values above recommended levels. HbA 1c, levels were significantly lower among patients with schizophrenia than among patients who did not have severe mental illness but were not significantly different from those of patients who had major mood disorders. Patients for whom olanzapine was prescribed had higher HbA 1c, levels than those for whom other antipsychotic agents were prescribed. Conclusions: All three groups of patients require improved diabetes treatment to achieve acceptable HbA 1c, levels. There may be previously unrecognized benefits for diabetes management among persons with severe mental illnesses who are receiving regular mental heath care, but these individuals may also have risk factors that can influence diabetes outcomes and HbA 1c levels.

Original languageEnglish (US)
Pages (from-to)892-900
Number of pages9
JournalPsychiatric Services
Issue number8
StatePublished - Aug 2004
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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