A Comparison of Two Dose Regimens of Epsilon Aminocaproic Acid in the Prevention and Management of Secondary Traumatic Hyphemas

David J. Palmer, Morton F. Goldberg, Marcel Frenkel, Richard Fiscella, Robert J. Anderson

Research output: Contribution to journalArticle


Fifty-nine patients who sustained hyphema following blunt trauma were randomly assigned prospectively to either of two dose regimens of epsilon aminocaproic acid (Amicar®). Twenty-six took an oral dosage of 50 mg/kg (“half dose”) every four hours for five days, up to a maximum of 30 g/day, and 33 patients received 100 mg/kg (“full-dose”) every four hours up to a maximum of 30 g/day. Five patients in the full-dose group experienced dizziness, hypotension, and syncope. Half-dose Amicar® substantially reduced such serious side effects (P = 0.063), had no adverse effect on the reduced rate of recurrent hemorrhages (P = 0.22), and was more cost effective than the full-dose regimen. When the two patients in the half-dose group receiving 30 g/day of Amicar® were deleted, however, the comparison of dizziness and hypotension in the two groups became more significant (P = 0.050). The incidence of nausea and vomiting was approximately the same in both groups (P = 0.52). Serum Amicar® levels were within the range of plasminogen inhibition at both dose levels. Prior aspirin ingestion appeared to have no influence on the rate of rebleeding (P =0.58).

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
Issue number1
StatePublished - Jan 1 1986
Externally publishedYes



  • epsilon aminocaproic acid
  • hyphema
  • rebleeding

ASJC Scopus subject areas

  • Ophthalmology

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