A comparison of the detection of sentinel lymph nodes using indocyanine green and near-infrared fluorescence imaging versus blue dye during robotic surgery in uterine cancer

Ane Gerda Eriksson, Anna Beavis, Robert A. Soslow, Qin Zhou, Nadeem R. Abu-Rustum, Ginger J. Gardner, Oliver Zivanovic, Kara Long Roche, Yukio Sonoda, Mario M. Leitao, Elizabeth L. Jewell

Research output: Contribution to journalArticle

Abstract

Objectives: The objective of this study was to assess and compare the sentinel lymph node (SLN) detection rate with indocyanine green (ICG) and near-infrared fluorescence imaging versus blue dye using the robotic platform in patients with uterine cancer. Methods: We identified all patients with uterine cancer undergoing SLN mapping using ICG or blue dye on the robotic platform from January 2011 to December 2013. Our institutional SLN algorithm and pathologic processing protocol were adhered to uniformly. We compared detection rates of SLNs stratified by dye used. Appropriate statistical tests were used. Results: A total of 472 patients were identified. ICG was used in 312 patients (66%) and blue dye in 160 patients (34%). Successful mapping was achieved in 425 (90%) of 472 patients. Mapping was bilateral in 352 patients (75%) and unilateral in 73 patients (15%); 47 patients (10%) did not map. Successful mapping was achieved in 295 (95%) of 312 patients using ICG compared with 130 (81%) of 160 patients using blue dye (P < 0.001). Mapping was bilateral in 266 (85%) of 312 patients in the ICG group compared with 86 (54%) of 160 in the blue dye group (P < 0.001). Additional lymph node dissection beyond removal of the SLNs was performed in 122 patients (39%) mapped with ICG compared with 98 patients (61%) mapped with blue dye (P < 0.001). Conclusions: The SLN detection rate was superior when mapping with ICG rather than blue dye. Bilateral mapping was significantly improved, resulting in a lower rate of additional lymphadenectomy.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume27
Issue number4
DOIs
StatePublished - Jan 1 2017

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Uterine Neoplasms
Indocyanine Green
Optical Imaging
Robotics
Coloring Agents
Sentinel Lymph Node
Lymph Node Excision

Keywords

  • Indocyanine green
  • Near-infrared fluorescence imaging
  • Robotic surgery
  • Sentinel lymph nodes
  • Uterine cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

A comparison of the detection of sentinel lymph nodes using indocyanine green and near-infrared fluorescence imaging versus blue dye during robotic surgery in uterine cancer. / Eriksson, Ane Gerda; Beavis, Anna; Soslow, Robert A.; Zhou, Qin; Abu-Rustum, Nadeem R.; Gardner, Ginger J.; Zivanovic, Oliver; Roche, Kara Long; Sonoda, Yukio; Leitao, Mario M.; Jewell, Elizabeth L.

In: International Journal of Gynecological Cancer, Vol. 27, No. 4, 01.01.2017, p. 743-747.

Research output: Contribution to journalArticle

Eriksson, Ane Gerda ; Beavis, Anna ; Soslow, Robert A. ; Zhou, Qin ; Abu-Rustum, Nadeem R. ; Gardner, Ginger J. ; Zivanovic, Oliver ; Roche, Kara Long ; Sonoda, Yukio ; Leitao, Mario M. ; Jewell, Elizabeth L. / A comparison of the detection of sentinel lymph nodes using indocyanine green and near-infrared fluorescence imaging versus blue dye during robotic surgery in uterine cancer. In: International Journal of Gynecological Cancer. 2017 ; Vol. 27, No. 4. pp. 743-747.
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abstract = "Objectives: The objective of this study was to assess and compare the sentinel lymph node (SLN) detection rate with indocyanine green (ICG) and near-infrared fluorescence imaging versus blue dye using the robotic platform in patients with uterine cancer. Methods: We identified all patients with uterine cancer undergoing SLN mapping using ICG or blue dye on the robotic platform from January 2011 to December 2013. Our institutional SLN algorithm and pathologic processing protocol were adhered to uniformly. We compared detection rates of SLNs stratified by dye used. Appropriate statistical tests were used. Results: A total of 472 patients were identified. ICG was used in 312 patients (66{\%}) and blue dye in 160 patients (34{\%}). Successful mapping was achieved in 425 (90{\%}) of 472 patients. Mapping was bilateral in 352 patients (75{\%}) and unilateral in 73 patients (15{\%}); 47 patients (10{\%}) did not map. Successful mapping was achieved in 295 (95{\%}) of 312 patients using ICG compared with 130 (81{\%}) of 160 patients using blue dye (P < 0.001). Mapping was bilateral in 266 (85{\%}) of 312 patients in the ICG group compared with 86 (54{\%}) of 160 in the blue dye group (P < 0.001). Additional lymph node dissection beyond removal of the SLNs was performed in 122 patients (39{\%}) mapped with ICG compared with 98 patients (61{\%}) mapped with blue dye (P < 0.001). Conclusions: The SLN detection rate was superior when mapping with ICG rather than blue dye. Bilateral mapping was significantly improved, resulting in a lower rate of additional lymphadenectomy.",
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T1 - A comparison of the detection of sentinel lymph nodes using indocyanine green and near-infrared fluorescence imaging versus blue dye during robotic surgery in uterine cancer

AU - Eriksson, Ane Gerda

AU - Beavis, Anna

AU - Soslow, Robert A.

AU - Zhou, Qin

AU - Abu-Rustum, Nadeem R.

AU - Gardner, Ginger J.

AU - Zivanovic, Oliver

AU - Roche, Kara Long

AU - Sonoda, Yukio

AU - Leitao, Mario M.

AU - Jewell, Elizabeth L.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives: The objective of this study was to assess and compare the sentinel lymph node (SLN) detection rate with indocyanine green (ICG) and near-infrared fluorescence imaging versus blue dye using the robotic platform in patients with uterine cancer. Methods: We identified all patients with uterine cancer undergoing SLN mapping using ICG or blue dye on the robotic platform from January 2011 to December 2013. Our institutional SLN algorithm and pathologic processing protocol were adhered to uniformly. We compared detection rates of SLNs stratified by dye used. Appropriate statistical tests were used. Results: A total of 472 patients were identified. ICG was used in 312 patients (66%) and blue dye in 160 patients (34%). Successful mapping was achieved in 425 (90%) of 472 patients. Mapping was bilateral in 352 patients (75%) and unilateral in 73 patients (15%); 47 patients (10%) did not map. Successful mapping was achieved in 295 (95%) of 312 patients using ICG compared with 130 (81%) of 160 patients using blue dye (P < 0.001). Mapping was bilateral in 266 (85%) of 312 patients in the ICG group compared with 86 (54%) of 160 in the blue dye group (P < 0.001). Additional lymph node dissection beyond removal of the SLNs was performed in 122 patients (39%) mapped with ICG compared with 98 patients (61%) mapped with blue dye (P < 0.001). Conclusions: The SLN detection rate was superior when mapping with ICG rather than blue dye. Bilateral mapping was significantly improved, resulting in a lower rate of additional lymphadenectomy.

AB - Objectives: The objective of this study was to assess and compare the sentinel lymph node (SLN) detection rate with indocyanine green (ICG) and near-infrared fluorescence imaging versus blue dye using the robotic platform in patients with uterine cancer. Methods: We identified all patients with uterine cancer undergoing SLN mapping using ICG or blue dye on the robotic platform from January 2011 to December 2013. Our institutional SLN algorithm and pathologic processing protocol were adhered to uniformly. We compared detection rates of SLNs stratified by dye used. Appropriate statistical tests were used. Results: A total of 472 patients were identified. ICG was used in 312 patients (66%) and blue dye in 160 patients (34%). Successful mapping was achieved in 425 (90%) of 472 patients. Mapping was bilateral in 352 patients (75%) and unilateral in 73 patients (15%); 47 patients (10%) did not map. Successful mapping was achieved in 295 (95%) of 312 patients using ICG compared with 130 (81%) of 160 patients using blue dye (P < 0.001). Mapping was bilateral in 266 (85%) of 312 patients in the ICG group compared with 86 (54%) of 160 in the blue dye group (P < 0.001). Additional lymph node dissection beyond removal of the SLNs was performed in 122 patients (39%) mapped with ICG compared with 98 patients (61%) mapped with blue dye (P < 0.001). Conclusions: The SLN detection rate was superior when mapping with ICG rather than blue dye. Bilateral mapping was significantly improved, resulting in a lower rate of additional lymphadenectomy.

KW - Indocyanine green

KW - Near-infrared fluorescence imaging

KW - Robotic surgery

KW - Sentinel lymph nodes

KW - Uterine cancer

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