A comparison of rice-based oral rehydration solution and "early feeding" for the treatment of acute diarrhea in infants

Mathuram Santosham, Ibrahim M. Fayad, Mohamed Hashem, Julius G. Goepp, Mamdouh Refaf, R. Bradley Sack

Research output: Contribution to journalArticlepeer-review

Abstract

To compare the use of rice-based oral rehydration solution (R-ORS), with the introduction of food immediately after rehydration ("early feeding"), using standard glucose-based oral rehydration solution (G-ORS) in the management of acute diarrhea, we conducted a four-cell randomized, controlled trial among 200 hospitalized Egyptian infants between 3 and 18 months of age. During the rehydration phase (first 4 hours), three groups were given G-ORS and a fourth group was given R-ORS. During the subsequent maintenance phase, the control group was given a soy-based, lactose-free formula (G-ORS+SF), a second group (G-ORS+RF) was given a rice-based formula, and a third group (G-ORS+rice) was given boiled rice. The fourth group (R-ORS+SF) continued to receive R-ORS for the first 24 hours of the maintenance period, followed by a soy-based lactose-free formula. During the first and second 24 hours of the maintenance period, infants in the three treatment groups had a lower mean stool output in comparison with the control group (p=0.006 and 0.03, respectively). The mean total stool output in the R-ORS+SF group was significantly lower than in the control group (p=0.02). There were no statistically significant differences among the four groups in the mean duration of diarrhea. We conclude that (1) infants who were given R-ORS had reduced total stool output (by 35%) compared with the control group and (2) feeding of boiled rice or a rice-based formula immediately after rehydration therapy was as efficacious as treatment with R-ORS alone for 24 hours, followed by feeding with a soy-based, lactose-free formula.

Original languageEnglish (US)
Pages (from-to)868-875
Number of pages8
JournalThe Journal of pediatrics
Volume116
Issue number6
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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