TY - JOUR
T1 - A comparison of rice-based oral rehydration solution and "early feeding" for the treatment of acute diarrhea in infants
AU - Santosham, Mathuram
AU - Fayad, Ibrahim M.
AU - Hashem, Mohamed
AU - Goepp, Julius G.
AU - Refaf, Mamdouh
AU - Sack, R. Bradley
N1 - Funding Information:
The use of various feeding regimens during acute diarrheal episodes has been the subject of intense investigation during the past few years. 14 " Recent studies have demonstrated Supported by a grant from the Mead Johnson Nutritional Group. Submitted for publication Aug. 4, 1989; accepted Nov. 15, 1989. Reprint requests: Mathuram Santosham, MD, Johns Hopkins University School of Hygiene and Public Health, 615 North Wolfe St., Room 5505, Baltimore, MD 21205. 9/20/18065 that infants with acute diarrhea have less stool output and shorter duration of diarrhea when they are fed a soy-based, lactose-free infant formula after the initial rehydration period than do infants who are given only oral rehydration solution for the first 48 hours of hospitalization. 2 Stool output is reduced in infants who are given human milk during the acute phase of diarrheal illness, compared with infants who are given only ORS during the acute phase of illness. 3 The relative efficacy of various cereal-based ORS formulations for the treatment of diarrhea has also been
PY - 1990/6
Y1 - 1990/6
N2 - To compare the use of rice-based oral rehydration solution (R-ORS), with the introduction of food immediately after rehydration ("early feeding"), using standard glucose-based oral rehydration solution (G-ORS) in the management of acute diarrhea, we conducted a four-cell randomized, controlled trial among 200 hospitalized Egyptian infants between 3 and 18 months of age. During the rehydration phase (first 4 hours), three groups were given G-ORS and a fourth group was given R-ORS. During the subsequent maintenance phase, the control group was given a soy-based, lactose-free formula (G-ORS+SF), a second group (G-ORS+RF) was given a rice-based formula, and a third group (G-ORS+rice) was given boiled rice. The fourth group (R-ORS+SF) continued to receive R-ORS for the first 24 hours of the maintenance period, followed by a soy-based lactose-free formula. During the first and second 24 hours of the maintenance period, infants in the three treatment groups had a lower mean stool output in comparison with the control group (p=0.006 and 0.03, respectively). The mean total stool output in the R-ORS+SF group was significantly lower than in the control group (p=0.02). There were no statistically significant differences among the four groups in the mean duration of diarrhea. We conclude that (1) infants who were given R-ORS had reduced total stool output (by 35%) compared with the control group and (2) feeding of boiled rice or a rice-based formula immediately after rehydration therapy was as efficacious as treatment with R-ORS alone for 24 hours, followed by feeding with a soy-based, lactose-free formula.
AB - To compare the use of rice-based oral rehydration solution (R-ORS), with the introduction of food immediately after rehydration ("early feeding"), using standard glucose-based oral rehydration solution (G-ORS) in the management of acute diarrhea, we conducted a four-cell randomized, controlled trial among 200 hospitalized Egyptian infants between 3 and 18 months of age. During the rehydration phase (first 4 hours), three groups were given G-ORS and a fourth group was given R-ORS. During the subsequent maintenance phase, the control group was given a soy-based, lactose-free formula (G-ORS+SF), a second group (G-ORS+RF) was given a rice-based formula, and a third group (G-ORS+rice) was given boiled rice. The fourth group (R-ORS+SF) continued to receive R-ORS for the first 24 hours of the maintenance period, followed by a soy-based lactose-free formula. During the first and second 24 hours of the maintenance period, infants in the three treatment groups had a lower mean stool output in comparison with the control group (p=0.006 and 0.03, respectively). The mean total stool output in the R-ORS+SF group was significantly lower than in the control group (p=0.02). There were no statistically significant differences among the four groups in the mean duration of diarrhea. We conclude that (1) infants who were given R-ORS had reduced total stool output (by 35%) compared with the control group and (2) feeding of boiled rice or a rice-based formula immediately after rehydration therapy was as efficacious as treatment with R-ORS alone for 24 hours, followed by feeding with a soy-based, lactose-free formula.
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U2 - 10.1016/S0022-3476(05)80642-0
DO - 10.1016/S0022-3476(05)80642-0
M3 - Article
C2 - 2112187
AN - SCOPUS:0025296719
SN - 0022-3476
VL - 116
SP - 868
EP - 875
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 6
ER -