A comparison of prostate cancer bone metastases on18F-sodium fluoride and prostate specific membrane antigen (18F-PSMA) PET/CT: Discordant uptake in the same lesion

Stephanie A. Harmon; Esther Mena; Joanna H. Shih; Stephen Adler; Yolanda McKinney; Ethan Bergvall; Sherif Mehralivand; Adam G. Sowalsky; Anna Couvillon; Ravi A. Madan; James L. Gulley; Janet Eary; Ronnie Mease; Martin Gilbert Pomper; William L. Dahut; Baris Turkbey; Liza Lindenberg; Peter L. Choyke

A comparison of prostate cancer bone metastases on¹⁸F-sodium fluoride and prostate specific membrane antigen (¹⁸F-PSMA) PET/CT: Discordant uptake in the same lesion

Stephanie A. Harmon, Esther Mena, Joanna H. Shih, Stephen Adler, Yolanda McKinney, Ethan Bergvall, Sherif Mehralivand, Adam G. Sowalsky, Anna Couvillon, Ravi A. Madan, James L. Gulley, Janet Eary, Ronnie Mease, Martin Gilbert Pomper, William L. Dahut, Baris Turkbey, Liza Lindenberg, Peter L. Choyke

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of ¹⁸F-NaF PET/CT and ¹⁸F-PSMA-targeted PET/CT within prostate cancer bone metastases. Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT ¹⁸F-DCFBC or ¹⁸F-DCFPyL) and ¹⁸F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status. Results: The study included 149 lesions in 19 patients. Qualitatively, lesions exhibited a heterogeneous range of spatial concordance between PSMA and NaF uptake from completely matched to completely discordant. Quantitatively, overlap volume decreased as a function of tracer intensity. and disease status, where lesions from patients with castration-sensitive disease showed higher spatial concordance while lesions from patients with castration-resistant disease demonstrated more frequent spatial discordance. Conclusion: As metastatic prostate cancer progresses from castration-sensitive to castration-resistant, greater discordance is observed between NaF PET and PSMA PET uptake. This may indicate a possible phenotypic shift to tumor growth that is more independent of bone remodeling via osteoblastic formation.

Original language	English (US)
Pages (from-to)	37676-37688
Number of pages	13
Journal	Oncotarget
Volume	9
Issue number	102
State	Published - Dec 1 2018

Keywords

Bone metastases
Prostate cancer
Prostate specific membrane antigen
Sodium fluoride
Spatial analysis

ASJC Scopus subject areas

Oncology

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Harmon, S. A., Mena, E., Shih, J. H., Adler, S., McKinney, Y., Bergvall, E., Mehralivand, S., Sowalsky, A. G., Couvillon, A., Madan, R. A., Gulley, J. L., Eary, J., Mease, R., Pomper, M. G., Dahut, W. L., Turkbey, B., Lindenberg, L., & Choyke, P. L. (2018). A comparison of prostate cancer bone metastases on¹⁸F-sodium fluoride and prostate specific membrane antigen (¹⁸F-PSMA) PET/CT: Discordant uptake in the same lesion. Oncotarget, 9(102), 37676-37688.

A comparison of prostate cancer bone metastases on¹⁸F-sodium fluoride and prostate specific membrane antigen (¹⁸F-PSMA) PET/CT : Discordant uptake in the same lesion. / Harmon, Stephanie A.; Mena, Esther; Shih, Joanna H.; Adler, Stephen; McKinney, Yolanda; Bergvall, Ethan; Mehralivand, Sherif; Sowalsky, Adam G.; Couvillon, Anna; Madan, Ravi A.; Gulley, James L.; Eary, Janet; Mease, Ronnie ; Pomper, Martin Gilbert; Dahut, William L.; Turkbey, Baris; Lindenberg, Liza; Choyke, Peter L.

In: Oncotarget, Vol. 9, No. 102, 01.12.2018, p. 37676-37688.

Research output: Contribution to journal › Article › peer-review

Harmon, SA, Mena, E, Shih, JH, Adler, S, McKinney, Y, Bergvall, E, Mehralivand, S, Sowalsky, AG, Couvillon, A, Madan, RA, Gulley, JL, Eary, J, Mease, R , Pomper, MG, Dahut, WL, Turkbey, B, Lindenberg, L & Choyke, PL 2018, 'A comparison of prostate cancer bone metastases on¹⁸F-sodium fluoride and prostate specific membrane antigen (¹⁸F-PSMA) PET/CT: Discordant uptake in the same lesion', Oncotarget, vol. 9, no. 102, pp. 37676-37688.

Harmon, Stephanie A. ; Mena, Esther ; Shih, Joanna H. ; Adler, Stephen ; McKinney, Yolanda ; Bergvall, Ethan ; Mehralivand, Sherif ; Sowalsky, Adam G. ; Couvillon, Anna ; Madan, Ravi A. ; Gulley, James L. ; Eary, Janet ; Mease, Ronnie ; Pomper, Martin Gilbert ; Dahut, William L. ; Turkbey, Baris ; Lindenberg, Liza ; Choyke, Peter L. / A comparison of prostate cancer bone metastases on¹⁸F-sodium fluoride and prostate specific membrane antigen (¹⁸F-PSMA) PET/CT : Discordant uptake in the same lesion. In: Oncotarget. 2018 ; Vol. 9, No. 102. pp. 37676-37688.

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title = "A comparison of prostate cancer bone metastases on18F-sodium fluoride and prostate specific membrane antigen (18F-PSMA) PET/CT: Discordant uptake in the same lesion",

abstract = "Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of 18F-NaF PET/CT and 18F-PSMA-targeted PET/CT within prostate cancer bone metastases. Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT 18F-DCFBC or 18F-DCFPyL) and 18F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status. Results: The study included 149 lesions in 19 patients. Qualitatively, lesions exhibited a heterogeneous range of spatial concordance between PSMA and NaF uptake from completely matched to completely discordant. Quantitatively, overlap volume decreased as a function of tracer intensity. and disease status, where lesions from patients with castration-sensitive disease showed higher spatial concordance while lesions from patients with castration-resistant disease demonstrated more frequent spatial discordance. Conclusion: As metastatic prostate cancer progresses from castration-sensitive to castration-resistant, greater discordance is observed between NaF PET and PSMA PET uptake. This may indicate a possible phenotypic shift to tumor growth that is more independent of bone remodeling via osteoblastic formation.",

keywords = "Bone metastases, Prostate cancer, Prostate specific membrane antigen, Sodium fluoride, Spatial analysis",

author = "Harmon, {Stephanie A.} and Esther Mena and Shih, {Joanna H.} and Stephen Adler and Yolanda McKinney and Ethan Bergvall and Sherif Mehralivand and Sowalsky, {Adam G.} and Anna Couvillon and Madan, {Ravi A.} and Gulley, {James L.} and Janet Eary and Ronnie Mease and Pomper, {Martin Gilbert} and Dahut, {William L.} and Baris Turkbey and Liza Lindenberg and Choyke, {Peter L.}",

year = "2018",

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T1 - A comparison of prostate cancer bone metastases on18F-sodium fluoride and prostate specific membrane antigen (18F-PSMA) PET/CT

T2 - Discordant uptake in the same lesion

AU - Harmon, Stephanie A.

AU - Mena, Esther

AU - Shih, Joanna H.

AU - Adler, Stephen

AU - McKinney, Yolanda

AU - Bergvall, Ethan

AU - Mehralivand, Sherif

AU - Sowalsky, Adam G.

AU - Couvillon, Anna

AU - Madan, Ravi A.

AU - Gulley, James L.

AU - Eary, Janet

AU - Mease, Ronnie

AU - Pomper, Martin Gilbert

AU - Dahut, William L.

AU - Turkbey, Baris

AU - Lindenberg, Liza

AU - Choyke, Peter L.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of 18F-NaF PET/CT and 18F-PSMA-targeted PET/CT within prostate cancer bone metastases. Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT 18F-DCFBC or 18F-DCFPyL) and 18F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status. Results: The study included 149 lesions in 19 patients. Qualitatively, lesions exhibited a heterogeneous range of spatial concordance between PSMA and NaF uptake from completely matched to completely discordant. Quantitatively, overlap volume decreased as a function of tracer intensity. and disease status, where lesions from patients with castration-sensitive disease showed higher spatial concordance while lesions from patients with castration-resistant disease demonstrated more frequent spatial discordance. Conclusion: As metastatic prostate cancer progresses from castration-sensitive to castration-resistant, greater discordance is observed between NaF PET and PSMA PET uptake. This may indicate a possible phenotypic shift to tumor growth that is more independent of bone remodeling via osteoblastic formation.

AB - Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of 18F-NaF PET/CT and 18F-PSMA-targeted PET/CT within prostate cancer bone metastases. Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT 18F-DCFBC or 18F-DCFPyL) and 18F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status. Results: The study included 149 lesions in 19 patients. Qualitatively, lesions exhibited a heterogeneous range of spatial concordance between PSMA and NaF uptake from completely matched to completely discordant. Quantitatively, overlap volume decreased as a function of tracer intensity. and disease status, where lesions from patients with castration-sensitive disease showed higher spatial concordance while lesions from patients with castration-resistant disease demonstrated more frequent spatial discordance. Conclusion: As metastatic prostate cancer progresses from castration-sensitive to castration-resistant, greater discordance is observed between NaF PET and PSMA PET uptake. This may indicate a possible phenotypic shift to tumor growth that is more independent of bone remodeling via osteoblastic formation.

KW - Bone metastases

KW - Prostate cancer

KW - Prostate specific membrane antigen

KW - Sodium fluoride

KW - Spatial analysis

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