TY - JOUR
T1 - A comparison of nine scales to detect depression in Parkinson disease
T2 - Which scale to use?
AU - Williams, J. R.
AU - Hirsch, E. S.
AU - Anderson, K.
AU - Bush, A. L.
AU - Goldstein, S. R.
AU - Grill, S.
AU - Lehmann, S.
AU - Little, J. T.
AU - Margolis, R. L.
AU - Palanci, J.
AU - Pontone, G.
AU - Weiss, H.
AU - Rabins, P.
AU - Marsh, L.
N1 - Funding Information:
The MOOD-PD study was funded by NIMH grant R01-MH069666 . Coauthors were also supported by NINDS grant P50-NS58377 (the Morris K. Udall Parkinson's Disease Research Center of Excellence at Johns Hopkins), NIA grant T32-AG027668 , the Department of Veterans Affairs, the Donna Jeanne Gault Baumann Fund, and the Weldon Hall Trust. This article reflects the views of the authors and should not be construed to represent the Food and Drug Administration's views or policies.
PY - 2012/3/27
Y1 - 2012/3/27
N2 - Objective: The Methods of Optimal Depression Detection in Parkinson's Disease (MOOD-PD) study compared the psychometric properties of 9 depression scales to provide guidance on scale selection in Parkinson disease (PD). Methods: Patients with PD (n 229) from community-based neurology practices completed 6 self-report scales (Beck Depression Inventory [BDI]-II, Center for Epidemiologic Studies Depression Rating Scale-Revised [CESD-R], 30-item Geriatric Depression Scale [GDS-30], Inventory of Depressive Symptoms-Patient [IDS-SR], Patient Health Questionnaire-9 [PHQ-9], and Unified Parkinson's Disease Rating Scale [UPDRS]-Part I) and were administered 3 clinician-rated scales (17-item Hamilton Depression Rating Scale [HAM-D-17], Inventory of Depressive Symptoms- Clinician [IDS-C], and Montgomery-Asberg Depression Rating Scale [MADRS] and a psychiatric interview. DSM-IV-TR diagnoses were established by an expert panel blinded to the self-reported rating scale data. Receiver operating characteristic curves were used to estimate the area under the curve (AUC) of each scale. Results: All scales performed better than chance (AUC 0.75-0.85). Sensitivity ranged from 0.66 to 0.85 and specificity ranged from 0.60 to 0.88. The UPDRS Depression item had a smaller AUC than the BDI-II, HAM-D-17, IDS-C, and MADRS. The CESD-R also had a smaller AUC than the MADRS. The remaining AUCs were statistically similar. Conclusions: The GDS-30 may be the most efficient depression screening scale to use in PD because of its brevity, favorable psychometric properties, and lack of copyright protection. However, all scales studied, except for the UPDRS Depression, are valid screening tools when PD-specific cutoff scores are used.
AB - Objective: The Methods of Optimal Depression Detection in Parkinson's Disease (MOOD-PD) study compared the psychometric properties of 9 depression scales to provide guidance on scale selection in Parkinson disease (PD). Methods: Patients with PD (n 229) from community-based neurology practices completed 6 self-report scales (Beck Depression Inventory [BDI]-II, Center for Epidemiologic Studies Depression Rating Scale-Revised [CESD-R], 30-item Geriatric Depression Scale [GDS-30], Inventory of Depressive Symptoms-Patient [IDS-SR], Patient Health Questionnaire-9 [PHQ-9], and Unified Parkinson's Disease Rating Scale [UPDRS]-Part I) and were administered 3 clinician-rated scales (17-item Hamilton Depression Rating Scale [HAM-D-17], Inventory of Depressive Symptoms- Clinician [IDS-C], and Montgomery-Asberg Depression Rating Scale [MADRS] and a psychiatric interview. DSM-IV-TR diagnoses were established by an expert panel blinded to the self-reported rating scale data. Receiver operating characteristic curves were used to estimate the area under the curve (AUC) of each scale. Results: All scales performed better than chance (AUC 0.75-0.85). Sensitivity ranged from 0.66 to 0.85 and specificity ranged from 0.60 to 0.88. The UPDRS Depression item had a smaller AUC than the BDI-II, HAM-D-17, IDS-C, and MADRS. The CESD-R also had a smaller AUC than the MADRS. The remaining AUCs were statistically similar. Conclusions: The GDS-30 may be the most efficient depression screening scale to use in PD because of its brevity, favorable psychometric properties, and lack of copyright protection. However, all scales studied, except for the UPDRS Depression, are valid screening tools when PD-specific cutoff scores are used.
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U2 - 10.1212/WNL.0b013e31824d587f
DO - 10.1212/WNL.0b013e31824d587f
M3 - Article
C2 - 22422897
AN - SCOPUS:84860801435
SN - 0028-3878
VL - 78
SP - 998
EP - 1006
JO - Neurology
JF - Neurology
IS - 13
ER -