A Comparison of Hepatitis B Virus Infection in HIV-infected and HIV-uninfected Participants Enrolled in a Multi-National Clinical Trial: HPTN 052

Amy E. Greer, San San Ou, Ethan Wilson, Estelle Piwowar-Manning, Michael S. Forman, Marybeth McCauley, Theresa Gamble, Cholticha Ruangyuttikarn, Mina C. Hosseinipour, Nagalingeswaran Kumarasamy, Mulinda Nyirenda, Beatriz Grinsztejn, Jose Henrique Pilotto, Natthapol Kosashunhanan, Marineide Gonçalves de Melo, Joseph Makhema, Victor Akelo, Ravindre Panchia, Sharlaa Badal-Faesen, Ying Q. ChenMyron S. Cohen, Susan Eshleman, Chloe L Thio, Alexandra Valsamakis

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(-)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multi-national clinical trial: HIV Prevention Trials Network (HPTN 052). METHOD:: HBV infection status at enrollment was compared between HIV(+) (N=1241) and HIV(-) (N=1232) from seven HBV-endemic countries. Hepatitis B e antigen (HBeAg) and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with Chi-square, Fisherʼs exact, and median tests. RESULTS:: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, 'HBcAb'; 24.7% HBcAb and anti-HB surface antibody positive, “recovered”), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(-) except for isolated HBV core antibody (HBcAb), which was more prevalent in HIV(+) than HIV(-) [10.1% vs. 7.7%, P=0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(-). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (ALT ≤ Grade 2, 12% vs. 5.2%, P=0.037; AST ≤ Grade 2, 26% vs. 6.0%, P<0.001), CD4 trended lower, and HIV RNA was similar. CONCLUSIONS:: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
StateAccepted/In press - Jul 26 2017

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Virus Diseases
Hepatitis B virus
Clinical Trials
HIV
Chronic Hepatitis B
Transaminases
Hepatitis B Antibodies
HIV Infections
Antibodies
DNA
RNA
Hepatitis B e Antigens
Coinfection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

A Comparison of Hepatitis B Virus Infection in HIV-infected and HIV-uninfected Participants Enrolled in a Multi-National Clinical Trial : HPTN 052. / Greer, Amy E.; Ou, San San; Wilson, Ethan; Piwowar-Manning, Estelle; Forman, Michael S.; McCauley, Marybeth; Gamble, Theresa; Ruangyuttikarn, Cholticha; Hosseinipour, Mina C.; Kumarasamy, Nagalingeswaran; Nyirenda, Mulinda; Grinsztejn, Beatriz; Pilotto, Jose Henrique; Kosashunhanan, Natthapol; Gonçalves de Melo, Marineide; Makhema, Joseph; Akelo, Victor; Panchia, Ravindre; Badal-Faesen, Sharlaa; Chen, Ying Q.; Cohen, Myron S.; Eshleman, Susan; Thio, Chloe L; Valsamakis, Alexandra.

In: Journal of Acquired Immune Deficiency Syndromes, 26.07.2017.

Research output: Contribution to journalArticle

Greer, AE, Ou, SS, Wilson, E, Piwowar-Manning, E, Forman, MS, McCauley, M, Gamble, T, Ruangyuttikarn, C, Hosseinipour, MC, Kumarasamy, N, Nyirenda, M, Grinsztejn, B, Pilotto, JH, Kosashunhanan, N, Gonçalves de Melo, M, Makhema, J, Akelo, V, Panchia, R, Badal-Faesen, S, Chen, YQ, Cohen, MS, Eshleman, S, Thio, CL & Valsamakis, A 2017, 'A Comparison of Hepatitis B Virus Infection in HIV-infected and HIV-uninfected Participants Enrolled in a Multi-National Clinical Trial: HPTN 052', Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/QAI.0000000000001511
Greer, Amy E. ; Ou, San San ; Wilson, Ethan ; Piwowar-Manning, Estelle ; Forman, Michael S. ; McCauley, Marybeth ; Gamble, Theresa ; Ruangyuttikarn, Cholticha ; Hosseinipour, Mina C. ; Kumarasamy, Nagalingeswaran ; Nyirenda, Mulinda ; Grinsztejn, Beatriz ; Pilotto, Jose Henrique ; Kosashunhanan, Natthapol ; Gonçalves de Melo, Marineide ; Makhema, Joseph ; Akelo, Victor ; Panchia, Ravindre ; Badal-Faesen, Sharlaa ; Chen, Ying Q. ; Cohen, Myron S. ; Eshleman, Susan ; Thio, Chloe L ; Valsamakis, Alexandra. / A Comparison of Hepatitis B Virus Infection in HIV-infected and HIV-uninfected Participants Enrolled in a Multi-National Clinical Trial : HPTN 052. In: Journal of Acquired Immune Deficiency Syndromes. 2017.
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title = "A Comparison of Hepatitis B Virus Infection in HIV-infected and HIV-uninfected Participants Enrolled in a Multi-National Clinical Trial: HPTN 052",
abstract = "OBJECTIVE:: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(-)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multi-national clinical trial: HIV Prevention Trials Network (HPTN 052). METHOD:: HBV infection status at enrollment was compared between HIV(+) (N=1241) and HIV(-) (N=1232) from seven HBV-endemic countries. Hepatitis B e antigen (HBeAg) and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with Chi-square, Fisherʼs exact, and median tests. RESULTS:: Among all participants, 33.6{\%} had HBV exposure without cHB (8.9{\%} isolated HBV core antibody, 'HBcAb'; 24.7{\%} HBcAb and anti-HB surface antibody positive, “recovered”), 4.3{\%} had cHB, 8.9{\%} were vaccinated, and 53.5{\%} were uninfected. Data were similar among HIV(+) and HIV(-) except for isolated HBV core antibody (HBcAb), which was more prevalent in HIV(+) than HIV(-) [10.1{\%} vs. 7.7{\%}, P=0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(-). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (ALT ≤ Grade 2, 12{\%} vs. 5.2{\%}, P=0.037; AST ≤ Grade 2, 26{\%} vs. 6.0{\%}, P<0.001), CD4 trended lower, and HIV RNA was similar. CONCLUSIONS:: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.",
author = "Greer, {Amy E.} and Ou, {San San} and Ethan Wilson and Estelle Piwowar-Manning and Forman, {Michael S.} and Marybeth McCauley and Theresa Gamble and Cholticha Ruangyuttikarn and Hosseinipour, {Mina C.} and Nagalingeswaran Kumarasamy and Mulinda Nyirenda and Beatriz Grinsztejn and Pilotto, {Jose Henrique} and Natthapol Kosashunhanan and {Gon{\cc}alves de Melo}, Marineide and Joseph Makhema and Victor Akelo and Ravindre Panchia and Sharlaa Badal-Faesen and Chen, {Ying Q.} and Cohen, {Myron S.} and Susan Eshleman and Thio, {Chloe L} and Alexandra Valsamakis",
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T1 - A Comparison of Hepatitis B Virus Infection in HIV-infected and HIV-uninfected Participants Enrolled in a Multi-National Clinical Trial

T2 - HPTN 052

AU - Greer, Amy E.

AU - Ou, San San

AU - Wilson, Ethan

AU - Piwowar-Manning, Estelle

AU - Forman, Michael S.

AU - McCauley, Marybeth

AU - Gamble, Theresa

AU - Ruangyuttikarn, Cholticha

AU - Hosseinipour, Mina C.

AU - Kumarasamy, Nagalingeswaran

AU - Nyirenda, Mulinda

AU - Grinsztejn, Beatriz

AU - Pilotto, Jose Henrique

AU - Kosashunhanan, Natthapol

AU - Gonçalves de Melo, Marineide

AU - Makhema, Joseph

AU - Akelo, Victor

AU - Panchia, Ravindre

AU - Badal-Faesen, Sharlaa

AU - Chen, Ying Q.

AU - Cohen, Myron S.

AU - Eshleman, Susan

AU - Thio, Chloe L

AU - Valsamakis, Alexandra

PY - 2017/7/26

Y1 - 2017/7/26

N2 - OBJECTIVE:: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(-)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multi-national clinical trial: HIV Prevention Trials Network (HPTN 052). METHOD:: HBV infection status at enrollment was compared between HIV(+) (N=1241) and HIV(-) (N=1232) from seven HBV-endemic countries. Hepatitis B e antigen (HBeAg) and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with Chi-square, Fisherʼs exact, and median tests. RESULTS:: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, 'HBcAb'; 24.7% HBcAb and anti-HB surface antibody positive, “recovered”), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(-) except for isolated HBV core antibody (HBcAb), which was more prevalent in HIV(+) than HIV(-) [10.1% vs. 7.7%, P=0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(-). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (ALT ≤ Grade 2, 12% vs. 5.2%, P=0.037; AST ≤ Grade 2, 26% vs. 6.0%, P<0.001), CD4 trended lower, and HIV RNA was similar. CONCLUSIONS:: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.

AB - OBJECTIVE:: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(-)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multi-national clinical trial: HIV Prevention Trials Network (HPTN 052). METHOD:: HBV infection status at enrollment was compared between HIV(+) (N=1241) and HIV(-) (N=1232) from seven HBV-endemic countries. Hepatitis B e antigen (HBeAg) and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with Chi-square, Fisherʼs exact, and median tests. RESULTS:: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, 'HBcAb'; 24.7% HBcAb and anti-HB surface antibody positive, “recovered”), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(-) except for isolated HBV core antibody (HBcAb), which was more prevalent in HIV(+) than HIV(-) [10.1% vs. 7.7%, P=0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(-). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (ALT ≤ Grade 2, 12% vs. 5.2%, P=0.037; AST ≤ Grade 2, 26% vs. 6.0%, P<0.001), CD4 trended lower, and HIV RNA was similar. CONCLUSIONS:: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.

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