A comparison of electrocardiographic changes observed during the "anoxemia test" on normal persons and on patients with coronary sclerosis

James E. Patterson, Thomas W. Clark, Robert L. Levy

Research output: Contribution to journalArticle

Abstract

1. 1. In 157 cases of coronary sclerosis, the anoxemia test was electrocardiographically positive in 49 per cent, and furnished presumptive evidence of coronary insufficiency, by the occurrence of pain, in another 20 per cent. It was thus helpful in the recognition of a diminished coronary reserve in 69 per cent. 2. 2. The RS-T deviation in each individual lead, as well as the total RS-T deviation in the four leads which were employed, was greater in the 157 patients with coronary sclerosis than in 136 normal persons. 3. 3. The amount of total RS-T deviation usually increased in linear fashion in relation to the duration of the period of anoxemia. Occasionally the degree of deviation rose to a peak level and then decreased, suggesting that compensatory mechanisms operated to bring about a favorable adjustment in coronary blood flow. 4. 4. Comparison of the results on different patients with coronary sclerosis showed no direct relationship between the duration of the test and the amount of total RS-T deviation; patients who breathed the lowoxygen mixture for twenty minutes did not tend to show greater RS-T deviation than those whose tests were terminated earlier because of pain. 5. 5. The incidence of significant T-wave change increased with the degree of total RS-T deviation. 6. 6. The combination of partial T-wave reversal and RS-T deviation of 1 mm. or more in Lead IVF, as the sole criterion of a positive test, was observed in less than 2 per cent of the cases of coronary sclerosis and was found with equal frequency in normal persons. Its use as a sign of a positive reaction has, therefore, been discontinued.

Original languageEnglish (US)
Pages (from-to)837-846
Number of pages10
JournalAmerican Heart Journal
Volume23
Issue number6
StatePublished - Jun 1942
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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