A comparison of bumetanide and furosemide in the treatment of ascites. Cooperative study

H. F. Herlong, F. M. Hunter, R. S. Koff, W. C. Maddrey

Research output: Contribution to journalArticle

Abstract

In a cooperative study by clinicians in three medical facilities, bumetanide was compared with furosemide in patients presenting with ascites, a complication of chronic liver disease. In an open, parallel, randomized trial, 43 patients received bumetanide and 16 patients received furosemide. They were treated for from one to 28 weeks. Weight loss and decrease in abdominal girth following diuretic action occurred in both groups but was statistically significant only in the bumetanide treated patients. Because of the small number of patients on furosemide, valid statistical analysis could not be obtained. No evidence of hepatic encephalopathy developed during this study, and only one patient on furosemide was discontinued as a result of severe electrolyte imbalance. Differences in changes of electrolytes and uric acid were not statistically significant in the two groups. The majority of drug-related abnormalities were the results of the pharmacologic activity of the diuretic.

Original languageEnglish (US)
Pages (from-to)701-705
Number of pages5
JournalJournal of Clinical Pharmacology
Volume21
Issue number11-12 II
StatePublished - 1981

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Herlong, H. F., Hunter, F. M., Koff, R. S., & Maddrey, W. C. (1981). A comparison of bumetanide and furosemide in the treatment of ascites. Cooperative study. Journal of Clinical Pharmacology, 21(11-12 II), 701-705.