In a randomized, double-blind clinical trial, 208 women who underwent abdominal hysterectomy received either cefazolin (N = 108) or moxalactam (N = 100) as perioperative antimicrobial prophylaxis. There were no differences between the two groups in rates of serious infection, minor wound infection, standard febrile morbidity, duration of hospitalization, proportion receiving other postoperative antibiotics, or rates of rehospitalization. Women who received moxalactam had significantly more urinary tract infections, 87% of which were caused by the enterococcus. It is concluded that perioperative prophylaxis with thirdgeneration cephalosporins is not justified at this time.
|Original language||English (US)|
|Number of pages||5|
|Journal||Obstetrics and gynecology|
|State||Published - Sep 1985|
ASJC Scopus subject areas
- Obstetrics and Gynecology