TY - JOUR
T1 - A comparative study of photic injury in four inbred strains of albino rats
AU - Borges, Jose M.
AU - Edward, Deepak P.
AU - Tso, Mark O.M.
N1 - Funding Information:
The help of R. J. Anderson, Ph.D., in analyzing the statistical data is gratefully acknowledged. This work was supported in part by Research Grant EY 1903 (Dr. Tso): Core Grant EY 1792 from the National Eye Institute and Research Grant 2506 from Instituto Nacional da Investigacao Cientifica Portugal (Dr. Borges).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - The effects of light damage were studied in four inbred strains of albino rats, Fischer (F344), Lewis (L), Wistar (W), and Buffalo (BUF). Thirty-five-day-old rats (3 from each strain) were kept in cyclic light for two weeks, after which they were exposed to constant fluorescent light (180-190 foot-candles, 490-580nm) for 24 hours. The rats were sacrificed 6 days after exposure. Photic injury to the exposed eyes was evaluated morphometrically by measuring the mean outer nuclear layer (ONL) thickness and qualitatively by light microscopy. Statistical analysis of the quantitative data revealed that the Lewis and Buffalo strains were more severely affected than the Wistar and Fischer strains. The effects of injury were more severe in the superior and temporal quadrants. Taking both quantitative and qualitative assessment into consideration, it appeared that, among the strains studied, the rats from the Lewis strain were most sensitive to photic damage. These findings support previous findings of differential light sensitivity and further suggest that similar variability occurs among inbred strains with type 1 light damage.
AB - The effects of light damage were studied in four inbred strains of albino rats, Fischer (F344), Lewis (L), Wistar (W), and Buffalo (BUF). Thirty-five-day-old rats (3 from each strain) were kept in cyclic light for two weeks, after which they were exposed to constant fluorescent light (180-190 foot-candles, 490-580nm) for 24 hours. The rats were sacrificed 6 days after exposure. Photic injury to the exposed eyes was evaluated morphometrically by measuring the mean outer nuclear layer (ONL) thickness and qualitatively by light microscopy. Statistical analysis of the quantitative data revealed that the Lewis and Buffalo strains were more severely affected than the Wistar and Fischer strains. The effects of injury were more severe in the superior and temporal quadrants. Taking both quantitative and qualitative assessment into consideration, it appeared that, among the strains studied, the rats from the Lewis strain were most sensitive to photic damage. These findings support previous findings of differential light sensitivity and further suggest that similar variability occurs among inbred strains with type 1 light damage.
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U2 - 10.3109/02713689008999576
DO - 10.3109/02713689008999576
M3 - Article
C2 - 2276280
AN - SCOPUS:0025148672
SN - 0271-3683
VL - 9
SP - 799
EP - 803
JO - Current Eye Research
JF - Current Eye Research
IS - 8
ER -