A comparative study of enflurane and halothane using systolic time intervals

J. A. Kaplan; E. D. Miller; D. R. Bailey

doi:10.1213/00000539-197603000-00031

A comparative study of enflurane and halothane using systolic time intervals

J. A. Kaplan, E. D. Miller, D. R. Bailey

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Abstract

The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end tidal and halothane 0.65% end tidal. These agents were studied first with 50% N₂O and then without N₂O. Systolic, diastolic, and mean arterial blood pressure were decreased more by enflurane than by halothane (p<0.05). However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/LVET) and a smaller 1/PEP² and ejection fraction. When N₂O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP² and the ejection fraction.

Original language	English (US)
Pages (from-to)	263-268
Number of pages	6
Journal	Anesthesia and analgesia
Volume	55
Issue number	2
DOIs	https://doi.org/10.1213/00000539-197603000-00031
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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title = "A comparative study of enflurane and halothane using systolic time intervals",

abstract = "The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end tidal and halothane 0.65% end tidal. These agents were studied first with 50% N2O and then without N2O. Systolic, diastolic, and mean arterial blood pressure were decreased more by enflurane than by halothane (p<0.05). However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/LVET) and a smaller 1/PEP2 and ejection fraction. When N2O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP2 and the ejection fraction.",

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T1 - A comparative study of enflurane and halothane using systolic time intervals

AU - Kaplan, J. A.

AU - Miller, E. D.

AU - Bailey, D. R.

PY - 1976

Y1 - 1976

N2 - The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end tidal and halothane 0.65% end tidal. These agents were studied first with 50% N2O and then without N2O. Systolic, diastolic, and mean arterial blood pressure were decreased more by enflurane than by halothane (p<0.05). However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/LVET) and a smaller 1/PEP2 and ejection fraction. When N2O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP2 and the ejection fraction.

AB - The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end tidal and halothane 0.65% end tidal. These agents were studied first with 50% N2O and then without N2O. Systolic, diastolic, and mean arterial blood pressure were decreased more by enflurane than by halothane (p<0.05). However, halothane caused significantly more myocardial depression than enflurane, as indicated by a larger preejection period (PEP) and preejection period/left ventricular ejection time (PEP/LVET) and a smaller 1/PEP2 and ejection fraction. When N2O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP2 and the ejection fraction.

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A comparative study of enflurane and halothane using systolic time intervals

Abstract

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