A comparative study of biomechanical simulators in deformable registration of brain tumor images

Evangelia I. Zacharaki, Cosmina S. Hogea, George Biros, Christos Davatzikos

Research output: Contribution to journalArticle

Abstract

Simulating the brain tissue deformation caused by tumor growth has been found to aid the deformable registration of brain tumor images. In this paper, we evaluate the impact that different biomechanical simulators have on the accuracy of deformable registration. We use two alternative frameworks for biomechanical simulations of mass effect in 3-D magnetic resonance (MR) brain images. The first one is based on a finite-element model of nonlinear elasticity and unstructured meshes using the commercial software package ABAQUS. The second one employs incremental linear elasticity and regular grids in a fictitious domain method. In practice, biomechanical simulations via the second approach may be at least ten times faster. Landmarks error and visual examination of the coregistered images indicate that the two alternative frameworks for biomechanical simulations lead to comparable results of deformable registration. Thus, the computationally less expensive biomechanical simulator offers a practical alternative for registration purposes.

Original languageEnglish (US)
Pages (from-to)1233-1236
Number of pages4
JournalIEEE Transactions on Biomedical Engineering
Volume55
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

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Tumors
Brain
Simulators
Elasticity
ABAQUS
Magnetic resonance
Software packages
Tissue

Keywords

  • Biomechanical model
  • Brain tumor
  • Deformable registration
  • Tumor growth simulation

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

A comparative study of biomechanical simulators in deformable registration of brain tumor images. / Zacharaki, Evangelia I.; Hogea, Cosmina S.; Biros, George; Davatzikos, Christos.

In: IEEE Transactions on Biomedical Engineering, Vol. 55, No. 3, 03.2008, p. 1233-1236.

Research output: Contribution to journalArticle

Zacharaki, Evangelia I. ; Hogea, Cosmina S. ; Biros, George ; Davatzikos, Christos. / A comparative study of biomechanical simulators in deformable registration of brain tumor images. In: IEEE Transactions on Biomedical Engineering. 2008 ; Vol. 55, No. 3. pp. 1233-1236.
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