TY - JOUR
T1 - A comparative evaluation of the anticancer properties of European and American elderberry fruits
AU - Thole, Julie M.
AU - Kraft, Tristan F.Burns
AU - Sueiro, Lilly Ann
AU - Kang, Young Hwa
AU - Gills, Joell J.
AU - Cuendet, Muriel
AU - Pezzuto, John M.
AU - Seigler, David S.
AU - Lila, Mary Ann
PY - 2006
Y1 - 2006
N2 - European elderberry (Sambucus nigra), recognized in Europe for its health-promoting properties for many generations, is known to contain a range of anthocyanins, flavonoids, and other polyphenolics that contribute to the high antioxidant capacity of its berries. American elderberry (Sambucus canadensis), on the other hand, has not been cultivated, bred, and promoted as a medicinal plant like its better-characterized European counterpart. In this study, aqueous acetone extracts of the berries from these two species were fractionated and tested in a range of assays that gauge anticarcinogenic potential. Both cultivated S. nigra and wild S. canadensis fruits demonstrated significant chemopreventive potential through strong induction of quinone reductase and inhibition of cyclooxygenase-2, which is indicative of anti-initiation and antipromotion properties, respectively. In addition, fractions of S. canadensis extract showed inhibition of ornithine decarboxylase, an enzyme marker related to the promotion stage of carcinogenesis. Analysis of active fractions using mass spectrometry and liquid chromatography-mass spectrometry revealed, in addition to flavonoids, the presence of more lipophilic compounds such as sesquiterpenes, iridoid monoterpene glycosides, and phytosterols.
AB - European elderberry (Sambucus nigra), recognized in Europe for its health-promoting properties for many generations, is known to contain a range of anthocyanins, flavonoids, and other polyphenolics that contribute to the high antioxidant capacity of its berries. American elderberry (Sambucus canadensis), on the other hand, has not been cultivated, bred, and promoted as a medicinal plant like its better-characterized European counterpart. In this study, aqueous acetone extracts of the berries from these two species were fractionated and tested in a range of assays that gauge anticarcinogenic potential. Both cultivated S. nigra and wild S. canadensis fruits demonstrated significant chemopreventive potential through strong induction of quinone reductase and inhibition of cyclooxygenase-2, which is indicative of anti-initiation and antipromotion properties, respectively. In addition, fractions of S. canadensis extract showed inhibition of ornithine decarboxylase, an enzyme marker related to the promotion stage of carcinogenesis. Analysis of active fractions using mass spectrometry and liquid chromatography-mass spectrometry revealed, in addition to flavonoids, the presence of more lipophilic compounds such as sesquiterpenes, iridoid monoterpene glycosides, and phytosterols.
KW - Bioactivity
KW - Flavonoids
KW - Iridoid monoterpenes
KW - Phenolics
KW - Sambucus spp.
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UR - http://www.scopus.com/inward/citedby.url?scp=33845357001&partnerID=8YFLogxK
U2 - 10.1089/jmf.2006.9.498
DO - 10.1089/jmf.2006.9.498
M3 - Article
C2 - 17201636
AN - SCOPUS:33845357001
SN - 1096-620X
VL - 9
SP - 498
EP - 504
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 4
ER -