A comparative evaluation of techniques for rapid and efficient in vivo labeling of red cells with [99mTc] pertechnetate.

R. G. Hamilton, P. O. Alderson

Research output: Contribution to journalArticlepeer-review

Abstract

Red blood cells (RBCs) labeled in vivo with 99mTcO4- have recently been recommended for blood-pool imaging, but the optimum conditions for in vivo labeling of RBCs have not been clearly defined. We therefore evaluated several stannous-ion preparations and stannous-ion concentrations to determine which provided the best labeling. The effect of the time interval between the Sn(II) and 99mTcO4- injections and the effect of carrier technetium on labeling efficiency were also studied. Maximal in vivo labeling efficiency was obtained using an intravenous dose of 10 microgram Sn(II)/kg followed 5-30 min later by an injection of 99mTcO4-. Neither the chelated form of stannous ion used in these studies nor the amount of carrier present had a significant effect on labeling efficiency. The biologic half-time of Tc-99m RBCs labeled in vivo was similar to that of Tc-99m RBCs labeled in vitro. In vivo labeling is a rapid and efficient method for the preparation of Tc-99m RBCs.

Original languageEnglish (US)
Pages (from-to)1010-1013
Number of pages4
JournalJournal of Nuclear Medicine
Volume18
Issue number10
StatePublished - Oct 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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