A compact laparoscopic probe for optical stimulation of the prostate nerves

Serhat Tozburun, Mona Mayeh, Gwen A. Lagoda, Faramarz Farahi, Arthur Burnett, Nathaniel M. Fried

Research output: Contribution to journalArticle

Abstract

The cavernous nerves (CN) course along the prostate surface and are responsible for sexual function. Optical nerve stimulation (ONS) has recently been tested as a potential alternative to electrical nerve stimulation for identifying and preserving these delicate nerves during prostate cancer surgery. However, the optimal range of laser parameters for safe and consistent laser nerve stimulation is relatively narrow; low-level irradiation may not stimulate the nerve, while high-level irradiation may result in thermal damage to the nerve and loss of erectile function. The objective of this study is to design, build, and provide preliminary data on testing of a laparoscopic probe capable of delivering a collimated, flat-top spatial beam profile to the nerve surface for uniform, safe, and reproducible irradiation of the nerve. Chemical etching of the distal fiber optic tip in combination with an aspheric lens resulted in a 3.4-mm-OD laparoscopic probe capable of delivering a collimated 1-mm-diameter, flat-top laser beam over a working distance of about 20 mm. Successful ONS using this probe was observed in a rat prostate model, in vivo. Upon further testing, this probe may be useful for identifying and preserving the CN during laparoscopic nerve-sparing prostate cancer surgery.

Original languageEnglish (US)
Article number5398871
Pages (from-to)941-945
Number of pages5
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume16
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

nerves
stimulation
probes
Irradiation
Surgery
Lasers
Testing
Fiber optics
Laser beams
Rats
Etching
Lenses
surgery
preserving
irradiation
cancer
rats
lasers
fiber optics
lenses

Keywords

  • Laser biomedical applications
  • nervous system
  • thulium
  • urinary system

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

A compact laparoscopic probe for optical stimulation of the prostate nerves. / Tozburun, Serhat; Mayeh, Mona; Lagoda, Gwen A.; Farahi, Faramarz; Burnett, Arthur; Fried, Nathaniel M.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 16, No. 4, 5398871, 07.2010, p. 941-945.

Research output: Contribution to journalArticle

Tozburun, Serhat ; Mayeh, Mona ; Lagoda, Gwen A. ; Farahi, Faramarz ; Burnett, Arthur ; Fried, Nathaniel M. / A compact laparoscopic probe for optical stimulation of the prostate nerves. In: IEEE Journal on Selected Topics in Quantum Electronics. 2010 ; Vol. 16, No. 4. pp. 941-945.
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