A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves

William C. Perkins, Gwen A. Lagoda, Arthur L. Burnett, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical nerve stimulation (ONS) has been commonly performed in the laboratory using high-power, pulsed, infrared (IR) lasers including Holmium:YAG, diode, and Thulium fiber lasers. However, the relatively high cost of these lasers in comparison with conventional electrical nerve stimulation (ENS) equipment may represent a significant barrier to widespread adoption of ONS. Optical stimulation of the prostate cavernous nerves (CNas) has recently been reported using lower cost, continuous-wave (CW), all-fiber-based diode lasers. This preliminary study describes further miniaturization and cost reduction of the ONS system in the form of a compact, lightweight, cordless, and inexpensive IR laser. A 140-mW, 1560-nm diode laser was integrated with a green aiming beam and delivery optics into a compact ONS system. Surface and subsurface ONS was performed in a total of 5 rats, in vivo, with measurement of an intracavernous pressure (ICP) response during CW laser irradiation for 30 s with a spot diameter of 0.7 mm. Short-term, CW ONS of the prostate CNas is feasible using a compact, inexpensive, batterypowered IR laser diode system. This ONS system may represent an alternative to ENS for laboratory studies, and with further development, a handheld option for ONS in the clinic to identify and preserve the CNas during prostate cancer surgery.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics X
PublisherSPIE
ISBN (Print)9780819498397
DOIs
StatePublished - Jan 1 2014
EventPhotonic Therapeutics and Diagnostics X - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8926
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics X
CountryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

Keywords

  • Cavernous nerves
  • Infrared
  • Laser
  • Neurovascular bundle
  • Optical nerve stimulation
  • Prostate

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Perkins, W. C., Lagoda, G. A., Burnett, A. L., & Fried, N. M. (2014). A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves. In Photonic Therapeutics and Diagnostics X [89261E] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8926). SPIE. https://doi.org/10.1117/12.2043189