A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves

William C. Perkins, Gwen A. Lagoda, Arthur Burnett, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical nerve stimulation (ONS) has been commonly performed in the laboratory using high-power, pulsed, infrared (IR) lasers including Holmium:YAG, diode, and Thulium fiber lasers. However, the relatively high cost of these lasers in comparison with conventional electrical nerve stimulation (ENS) equipment may represent a significant barrier to widespread adoption of ONS. Optical stimulation of the prostate cavernous nerves (CNas) has recently been reported using lower cost, continuous-wave (CW), all-fiber-based diode lasers. This preliminary study describes further miniaturization and cost reduction of the ONS system in the form of a compact, lightweight, cordless, and inexpensive IR laser. A 140-mW, 1560-nm diode laser was integrated with a green aiming beam and delivery optics into a compact ONS system. Surface and subsurface ONS was performed in a total of 5 rats, in vivo, with measurement of an intracavernous pressure (ICP) response during CW laser irradiation for 30 s with a spot diameter of 0.7 mm. Short-term, CW ONS of the prostate CNas is feasible using a compact, inexpensive, batterypowered IR laser diode system. This ONS system may represent an alternative to ENS for laboratory studies, and with further development, a handheld option for ONS in the clinic to identify and preserve the CNas during prostate cancer surgery.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8926
ISBN (Print)9780819498397
DOIs
StatePublished - 2014
EventPhotonic Therapeutics and Diagnostics X - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Other

OtherPhotonic Therapeutics and Diagnostics X
CountryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

Fingerprint

Infrared lasers
nerves
stimulation
infrared lasers
rats
continuous radiation
Semiconductor lasers
Rats
Prostate
Lasers
Semiconductor Lasers
Thulium
Holmium
Continuous wave lasers
Costs and Cost Analysis
Electric Stimulation
Laser beam effects
Fiber lasers
Cost reduction
Surgery

Keywords

  • Cavernous nerves
  • Infrared
  • Laser
  • Neurovascular bundle
  • Optical nerve stimulation
  • Prostate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials

Cite this

Perkins, W. C., Lagoda, G. A., Burnett, A., & Fried, N. M. (2014). A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8926). [89261E] SPIE. https://doi.org/10.1117/12.2043189

A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves. / Perkins, William C.; Lagoda, Gwen A.; Burnett, Arthur; Fried, Nathaniel M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8926 SPIE, 2014. 89261E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Perkins, WC, Lagoda, GA, Burnett, A & Fried, NM 2014, A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8926, 89261E, SPIE, Photonic Therapeutics and Diagnostics X, San Francisco, CA, United States, 2/1/14. https://doi.org/10.1117/12.2043189
Perkins WC, Lagoda GA, Burnett A, Fried NM. A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8926. SPIE. 2014. 89261E https://doi.org/10.1117/12.2043189
Perkins, William C. ; Lagoda, Gwen A. ; Burnett, Arthur ; Fried, Nathaniel M. / A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8926 SPIE, 2014.
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