A common variant in the SETD7 gene predicts serum lycopene concentrations

Christopher R. D’Adamo, Antonietta D’Urso, Kathleen A. Ryan, Laura M. Yerges-Armstrong, Richard David Semba, Nanette I. Steinle, Braxton D. Mitchell, Alan R. Shuldiner, Patrick F. McArdle

Research output: Contribution to journalArticle

Abstract

Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum lycopene concentrations are under partial genetic control. The goal of this research was to identify genetic predictors of serum lycopene concentrations using the genome-wide association study (GWAS) approach among a sample of 441 Old Order Amish adults that consumed a controlled diet. Linear regression models were utilized to evaluate associations between genetic variants and serum concentrations of lycopene. Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 × 10−9). Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region. This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer. Further investigation into this relationship might help provide greater mechanistic understanding of these associations.

Original languageEnglish (US)
Article number82
JournalNutrients
Volume8
Issue number2
DOIs
StatePublished - 2016

Fingerprint

lycopene
Serum
Genes
genes
prostatic neoplasms
Linear Models
Prostatic Neoplasms
Amish
Chromosomes, Human, Pair 4
Genome-Wide Association Study
chronic diseases
Introns
Single Nucleotide Polymorphism
introns
food intake
public health
Chronic Disease
Public Health
Diet
chromosomes

Keywords

  • Carotenoids
  • Genome-wide association study (GWAS)
  • Lycopene
  • Old order amish
  • Prostate cancer
  • SCARB1
  • SETD7

ASJC Scopus subject areas

  • Food Science

Cite this

D’Adamo, C. R., D’Urso, A., Ryan, K. A., Yerges-Armstrong, L. M., Semba, R. D., Steinle, N. I., ... McArdle, P. F. (2016). A common variant in the SETD7 gene predicts serum lycopene concentrations. Nutrients, 8(2), [82]. https://doi.org/10.3390/nu8020082

A common variant in the SETD7 gene predicts serum lycopene concentrations. / D’Adamo, Christopher R.; D’Urso, Antonietta; Ryan, Kathleen A.; Yerges-Armstrong, Laura M.; Semba, Richard David; Steinle, Nanette I.; Mitchell, Braxton D.; Shuldiner, Alan R.; McArdle, Patrick F.

In: Nutrients, Vol. 8, No. 2, 82, 2016.

Research output: Contribution to journalArticle

D’Adamo, CR, D’Urso, A, Ryan, KA, Yerges-Armstrong, LM, Semba, RD, Steinle, NI, Mitchell, BD, Shuldiner, AR & McArdle, PF 2016, 'A common variant in the SETD7 gene predicts serum lycopene concentrations', Nutrients, vol. 8, no. 2, 82. https://doi.org/10.3390/nu8020082
D’Adamo CR, D’Urso A, Ryan KA, Yerges-Armstrong LM, Semba RD, Steinle NI et al. A common variant in the SETD7 gene predicts serum lycopene concentrations. Nutrients. 2016;8(2). 82. https://doi.org/10.3390/nu8020082
D’Adamo, Christopher R. ; D’Urso, Antonietta ; Ryan, Kathleen A. ; Yerges-Armstrong, Laura M. ; Semba, Richard David ; Steinle, Nanette I. ; Mitchell, Braxton D. ; Shuldiner, Alan R. ; McArdle, Patrick F. / A common variant in the SETD7 gene predicts serum lycopene concentrations. In: Nutrients. 2016 ; Vol. 8, No. 2.
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