A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Timothy M. Frayling, Nicholas J. Timpson, Michael N. Weedon, Eleftheria Zeggini, Rachel M. Freathy, Cecilia M. Lindgren, John R B Perry, Katherine S. Elliott, Hana Lango, Nigel W. Rayner, Beverley Shields, Lorna W. Harries, Jeffrey C. Barrett, Sian Ellard, Christopher J. Groves, Bridget Knight, Ann Marie Patch, Andrew R. Ness, Shah Ebrahim, Debbie A. Lawlor & 21 others Susan M. Ring, Yoav Ben-Shlomo, Marjo Riitta Jarvelin, Ulla Sovio, Amanda J. Bennett, David Melzer, Luigi Ferrucci, Ruth J F Loos, Inês Barroso, Nicholas J. Wareham, Fredrik Karpe, Katharine R. Owen, Lon R. Cardon, Mark Walker, Graham A. Hitman, Colin N A Palmer, Alex S F Doney, Andrew D. Morris, George Davey Smith, Andrew T. Hattersley, Mark I. McCarthy

Research output: Contribution to journalArticle

Abstract

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (SMI). An additive association of the variant with Ml was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

Original languageEnglish (US)
Pages (from-to)889-894
Number of pages6
JournalScience
Volume316
Issue number5826
DOIs
StatePublished - May 11 2007
Externally publishedYes

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Pediatric Obesity
Body Mass Index
Obesity
Genes
Fats
Alleles
Causality
Type 2 Diabetes Mellitus
Genome

ASJC Scopus subject areas

  • General

Cite this

Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., ... McCarthy, M. I. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. https://doi.org/10.1126/science.1141634

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. / Frayling, Timothy M.; Timpson, Nicholas J.; Weedon, Michael N.; Zeggini, Eleftheria; Freathy, Rachel M.; Lindgren, Cecilia M.; Perry, John R B; Elliott, Katherine S.; Lango, Hana; Rayner, Nigel W.; Shields, Beverley; Harries, Lorna W.; Barrett, Jeffrey C.; Ellard, Sian; Groves, Christopher J.; Knight, Bridget; Patch, Ann Marie; Ness, Andrew R.; Ebrahim, Shah; Lawlor, Debbie A.; Ring, Susan M.; Ben-Shlomo, Yoav; Jarvelin, Marjo Riitta; Sovio, Ulla; Bennett, Amanda J.; Melzer, David; Ferrucci, Luigi; Loos, Ruth J F; Barroso, Inês; Wareham, Nicholas J.; Karpe, Fredrik; Owen, Katharine R.; Cardon, Lon R.; Walker, Mark; Hitman, Graham A.; Palmer, Colin N A; Doney, Alex S F; Morris, Andrew D.; Smith, George Davey; Hattersley, Andrew T.; McCarthy, Mark I.

In: Science, Vol. 316, No. 5826, 11.05.2007, p. 889-894.

Research output: Contribution to journalArticle

Frayling, TM, Timpson, NJ, Weedon, MN, Zeggini, E, Freathy, RM, Lindgren, CM, Perry, JRB, Elliott, KS, Lango, H, Rayner, NW, Shields, B, Harries, LW, Barrett, JC, Ellard, S, Groves, CJ, Knight, B, Patch, AM, Ness, AR, Ebrahim, S, Lawlor, DA, Ring, SM, Ben-Shlomo, Y, Jarvelin, MR, Sovio, U, Bennett, AJ, Melzer, D, Ferrucci, L, Loos, RJF, Barroso, I, Wareham, NJ, Karpe, F, Owen, KR, Cardon, LR, Walker, M, Hitman, GA, Palmer, CNA, Doney, ASF, Morris, AD, Smith, GD, Hattersley, AT & McCarthy, MI 2007, 'A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity', Science, vol. 316, no. 5826, pp. 889-894. https://doi.org/10.1126/science.1141634
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007 May 11;316(5826):889-894. https://doi.org/10.1126/science.1141634
Frayling, Timothy M. ; Timpson, Nicholas J. ; Weedon, Michael N. ; Zeggini, Eleftheria ; Freathy, Rachel M. ; Lindgren, Cecilia M. ; Perry, John R B ; Elliott, Katherine S. ; Lango, Hana ; Rayner, Nigel W. ; Shields, Beverley ; Harries, Lorna W. ; Barrett, Jeffrey C. ; Ellard, Sian ; Groves, Christopher J. ; Knight, Bridget ; Patch, Ann Marie ; Ness, Andrew R. ; Ebrahim, Shah ; Lawlor, Debbie A. ; Ring, Susan M. ; Ben-Shlomo, Yoav ; Jarvelin, Marjo Riitta ; Sovio, Ulla ; Bennett, Amanda J. ; Melzer, David ; Ferrucci, Luigi ; Loos, Ruth J F ; Barroso, Inês ; Wareham, Nicholas J. ; Karpe, Fredrik ; Owen, Katharine R. ; Cardon, Lon R. ; Walker, Mark ; Hitman, Graham A. ; Palmer, Colin N A ; Doney, Alex S F ; Morris, Andrew D. ; Smith, George Davey ; Hattersley, Andrew T. ; McCarthy, Mark I. / A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. In: Science. 2007 ; Vol. 316, No. 5826. pp. 889-894.
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AU - Walker, Mark

AU - Hitman, Graham A.

AU - Palmer, Colin N A

AU - Doney, Alex S F

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