A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Timothy M. Frayling; Nicholas J. Timpson; Michael N. Weedon; Eleftheria Zeggini; Rachel M. Freathy; Cecilia M. Lindgren; John R B Perry; Katherine S. Elliott; Hana Lango; Nigel W. Rayner; Beverley Shields; Lorna W. Harries; Jeffrey C. Barrett; Sian Ellard; Christopher J. Groves; Bridget Knight; Ann Marie Patch; Andrew R. Ness; Shah Ebrahim; Debbie A. Lawlor; Susan M. Ring; Yoav Ben-Shlomo; Marjo Riitta Jarvelin; Ulla Sovio; Amanda J. Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J. Wareham; Fredrik Karpe; Katharine R. Owen; Lon R. Cardon; Mark Walker; Graham A. Hitman; Colin N A Palmer; Alex S F Doney; Andrew D. Morris; George Davey Smith; Andrew T. Hattersley; Mark I. McCarthy

doi:10.1126/science.1141634

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Timothy M. Frayling, Nicholas J. Timpson, Michael N. Weedon, Eleftheria Zeggini, Rachel M. Freathy, Cecilia M. Lindgren, John R B Perry, Katherine S. Elliott, Hana Lango, Nigel W. Rayner, Beverley Shields, Lorna W. Harries, Jeffrey C. Barrett, Sian Ellard, Christopher J. Groves, Bridget Knight, Ann Marie Patch, Andrew R. Ness, Shah Ebrahim, Debbie A. LawlorSusan M. Ring, Yoav Ben-Shlomo, Marjo Riitta Jarvelin, Ulla Sovio, Amanda J. Bennett, David Melzer, Luigi Ferrucci, Ruth J F Loos, Inês Barroso, Nicholas J. Wareham, Fredrik Karpe, Katharine R. Owen, Lon R. Cardon, Mark Walker, Graham A. Hitman, Colin N A Palmer, Alex S F Doney, Andrew D. Morris, George Davey Smith, Andrew T. Hattersley, Mark I. McCarthy

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Abstract

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (SMI). An additive association of the variant with Ml was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

Original language	English (US)
Pages (from-to)	889-894
Number of pages	6
Journal	Science
Volume	316
Issue number	5826
DOIs	https://doi.org/10.1126/science.1141634
State	Published - May 11 2007
Externally published	Yes

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Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., Shields, B., Harries, L. W., Barrett, J. C., Ellard, S., Groves, C. J., Knight, B., Patch, A. M., Ness, A. R., Ebrahim, S., ... McCarthy, M. I. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. https://doi.org/10.1126/science.1141634

Frayling, TM, Timpson, NJ, Weedon, MN, Zeggini, E, Freathy, RM, Lindgren, CM, Perry, JRB, Elliott, KS, Lango, H, Rayner, NW, Shields, B, Harries, LW, Barrett, JC, Ellard, S, Groves, CJ, Knight, B, Patch, AM, Ness, AR, Ebrahim, S, Lawlor, DA, Ring, SM, Ben-Shlomo, Y, Jarvelin, MR, Sovio, U, Bennett, AJ, Melzer, D, Ferrucci, L, Loos, RJF, Barroso, I, Wareham, NJ, Karpe, F, Owen, KR, Cardon, LR, Walker, M, Hitman, GA, Palmer, CNA, Doney, ASF, Morris, AD, Smith, GD, Hattersley, AT & McCarthy, MI 2007, 'A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity', Science, vol. 316, no. 5826, pp. 889-894. https://doi.org/10.1126/science.1141634

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title = "A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity",

abstract = "Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (SMI). An additive association of the variant with Ml was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.",

author = "Frayling, {Timothy M.} and Timpson, {Nicholas J.} and Weedon, {Michael N.} and Eleftheria Zeggini and Freathy, {Rachel M.} and Lindgren, {Cecilia M.} and Perry, {John R B} and Elliott, {Katherine S.} and Hana Lango and Rayner, {Nigel W.} and Beverley Shields and Harries, {Lorna W.} and Barrett, {Jeffrey C.} and Sian Ellard and Groves, {Christopher J.} and Bridget Knight and Patch, {Ann Marie} and Ness, {Andrew R.} and Shah Ebrahim and Lawlor, {Debbie A.} and Ring, {Susan M.} and Yoav Ben-Shlomo and Jarvelin, {Marjo Riitta} and Ulla Sovio and Bennett, {Amanda J.} and David Melzer and Luigi Ferrucci and Loos, {Ruth J F} and In{\^e}s Barroso and Wareham, {Nicholas J.} and Fredrik Karpe and Owen, {Katharine R.} and Cardon, {Lon R.} and Mark Walker and Hitman, {Graham A.} and Palmer, {Colin N A} and Doney, {Alex S F} and Morris, {Andrew D.} and Smith, {George Davey} and Hattersley, {Andrew T.} and McCarthy, {Mark I.}",

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AU - Timpson, Nicholas J.

AU - Weedon, Michael N.

AU - Zeggini, Eleftheria

AU - Freathy, Rachel M.

AU - Lindgren, Cecilia M.

AU - Perry, John R B

AU - Elliott, Katherine S.

AU - Lango, Hana

AU - Rayner, Nigel W.

AU - Shields, Beverley

AU - Harries, Lorna W.

AU - Barrett, Jeffrey C.

AU - Ellard, Sian

AU - Groves, Christopher J.

AU - Knight, Bridget

AU - Patch, Ann Marie

AU - Ness, Andrew R.

AU - Ebrahim, Shah

AU - Lawlor, Debbie A.

AU - Ring, Susan M.

AU - Ben-Shlomo, Yoav

AU - Jarvelin, Marjo Riitta

AU - Sovio, Ulla

AU - Bennett, Amanda J.

AU - Melzer, David

AU - Ferrucci, Luigi

AU - Loos, Ruth J F

AU - Barroso, Inês

AU - Wareham, Nicholas J.

AU - Karpe, Fredrik

AU - Owen, Katharine R.

AU - Cardon, Lon R.

AU - Walker, Mark

AU - Hitman, Graham A.

AU - Palmer, Colin N A

AU - Doney, Alex S F

AU - Morris, Andrew D.

AU - Smith, George Davey

AU - Hattersley, Andrew T.

AU - McCarthy, Mark I.

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AB - Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (SMI). An additive association of the variant with Ml was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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