A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets

Richard J. Montali, Charles A. Scanga, Douglas Pernikoff, David R. Wessner, Richard Ward, Kathryn V. Holmes

Research output: Contribution to journalArticle

Abstract

Callitrichid hepatitis (CH) is a highly fatal, emerging arenavirus disease of captive South American marmosets and tamarins (Callitrichidae), including the endangered golden lion tamarin. A common-source outbreak of CH in golden lion tamarins and pygmy marmosets at a US zoo resulted from a single feeding of the primates with newborn mice inapparently infected with lymphocytic choriomeningitis virus (LCMV). Isolates from livers of mice and primates were related to isolates from previous CH outbreaks and to laboratory strains of LCMV by serology and nucleic acid hybridization, and 2 surviving animals developed antibody to other LCMVCH isolates and to laboratory strains of LCMV. Thus, LCMV, an arenavirus prevalent in wild mice in the US, can cause sporadic fatal hepatic disease in primates. Exposure of humans to wild or laboratory mice or to marmosets and tamarins that are infected with wild-type strains of LCMV poses the danger of serious disease.

Original languageEnglish (US)
Pages (from-to)946-950
Number of pages5
JournalJournal of Infectious Diseases
Volume167
Issue number4
StatePublished - Apr 1993
Externally publishedYes

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Leontopithecus
Lymphocytic choriomeningitis virus
Callithrix
Hepatitis
Disease Outbreaks
Arenavirus
Primates
Primate Diseases
Callitrichinae
Nucleic Acid Hybridization
Liver
Serology
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Montali, R. J., Scanga, C. A., Pernikoff, D., Wessner, D. R., Ward, R., & Holmes, K. V. (1993). A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets. Journal of Infectious Diseases, 167(4), 946-950.

A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets. / Montali, Richard J.; Scanga, Charles A.; Pernikoff, Douglas; Wessner, David R.; Ward, Richard; Holmes, Kathryn V.

In: Journal of Infectious Diseases, Vol. 167, No. 4, 04.1993, p. 946-950.

Research output: Contribution to journalArticle

Montali, RJ, Scanga, CA, Pernikoff, D, Wessner, DR, Ward, R & Holmes, KV 1993, 'A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets', Journal of Infectious Diseases, vol. 167, no. 4, pp. 946-950.
Montali RJ, Scanga CA, Pernikoff D, Wessner DR, Ward R, Holmes KV. A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets. Journal of Infectious Diseases. 1993 Apr;167(4):946-950.
Montali, Richard J. ; Scanga, Charles A. ; Pernikoff, Douglas ; Wessner, David R. ; Ward, Richard ; Holmes, Kathryn V. / A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets. In: Journal of Infectious Diseases. 1993 ; Vol. 167, No. 4. pp. 946-950.
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