A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function

Heike Tost, Bhaskar Kolachana, Shabnam Hakimi, Herve Lemaitre, Beth A. Verchinski, Venkata Mattay, Daniel Weinberger, Andreas Meyer-Lindenberg

Research output: Contribution to journalArticle

Abstract

The evolutionarily highly conserved neuropeptide oxytocin is a key mediator of social and emotional behavior in mammals, including humans. A common variant (rs53576) in the oxytocin receptor gene (OXTR) has been implicated in social-behavioral phenotypes, such as maternal sensitivity and empathy, and with neuropsychiatric disorders associated with social impairment, but the intermediate neural mechanisms are unknown. Here, we used multimodal neuroimaging in a large sample of healthy human subjects to identify structural and functional alterations in OXTR risk allele carriers and their link to temperament. Activation and interregional coupling of the amygdala during the processing of emotionally salient social cues was significantly affected by genotype. In addition, evidence for structural alterations in key oxytocinergic regions emerged, particularly in the hypothalamus. These neural characteristics predicted lower levels of reward dependence, specifically in male risk allele carriers. Our findings identify sex-dependent mechanisms impacting the structure and function of hypothalamic-limbic circuits that are of potential clinical and translational significance.

Original languageEnglish (US)
Pages (from-to)13936-13941
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number31
DOIs
StatePublished - Aug 3 2010
Externally publishedYes

Fingerprint

Oxytocin Receptors
Temperament
Alleles
Oxytocin
Amygdala
Neuropeptides
Reward
Neuroimaging
Genes
Hypothalamus
Cues
Mammals
Healthy Volunteers
Genotype
Mothers
Phenotype

Keywords

  • Autism
  • Imaging genetics
  • Neuroimaging
  • Prosocial neuropeptides
  • Social behavior

ASJC Scopus subject areas

  • General

Cite this

A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. / Tost, Heike; Kolachana, Bhaskar; Hakimi, Shabnam; Lemaitre, Herve; Verchinski, Beth A.; Mattay, Venkata; Weinberger, Daniel; Meyer-Lindenberg, Andreas.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 31, 03.08.2010, p. 13936-13941.

Research output: Contribution to journalArticle

Tost, Heike ; Kolachana, Bhaskar ; Hakimi, Shabnam ; Lemaitre, Herve ; Verchinski, Beth A. ; Mattay, Venkata ; Weinberger, Daniel ; Meyer-Lindenberg, Andreas. / A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 31. pp. 13936-13941.
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