A combined behavioral/pharmacological treatment of sleep-wake schedule disorder in angelman syndrome

Jane A. Summers, Patricia S. Lynch, James C O Harris, John C. Burke, David B. Allison, Louis Sandler

Research output: Contribution to journalArticle

Abstract

Angelman syndrome (AS) is a genetic disorder associated with a deletion on chromosome 15. Behavior problems among children with AS include sleep difficulties. Data are presented on the successful treatment of a sleep-wake schedule disorder (SWSD) in a 9-year-old boy with AS. The treatment program included behavioral and pharmacological components. During baseline, the child slept a mean of 1.9 hours per night and 1.3 hours during the day; night sleep was increased to a mean of 8.3 hours and day sleep was reduced to a mean of.08 hours after introduction of the full-treatment program. Medication was discontinued subsequently, and the child slept a mean of 7.8 hours during the night and.07 hours during the day. At 45-day follow-up, night sleep was maintained at 7.1 hours and day sleep remained stable at.29 hours. This is the first known report of an effective treatment of a SWSD in a child with AS.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalJournal of Developmental and Behavioral Pediatrics
Volume13
Issue number4
Publication statusPublished - 1992

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Keywords

  • Angelman syndrome
  • behavioral treatment
  • pharmacotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Behavioral Neuroscience
  • Psychology(all)

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