A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

Pere Puigserver, Zhidan Wu, Cheol Won Park, Reed Graves, Margaret Wright, Bruce M. Spiegelman

Research output: Contribution to journalArticlepeer-review

Abstract

Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1, from a brown fat cDNA library. PGC-1 mRNA expression is dramatically elevated upon cold exposure of mice in both brown fat and skeletal muscle, key thermogenic tissues. PGC-1 greatly increases the transcriptional activity of PPARγ and the thyroid hormone receptor on the uncoupling protein (UCP-1) promoter. Ectopic expression of PGC-1 in white adipose cells activates expression of UCP-1 and key mitochondrial enzymes of the respiratory chain, and increases the cellular content of mitochondrial DNA. These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.

Original languageEnglish (US)
Pages (from-to)829-839
Number of pages11
JournalCell
Volume92
Issue number6
DOIs
StatePublished - Mar 20 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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