A cocaine analog and a GBR analog label the same protein in rat striatal membranes

Amrat Patel, John W. Boja, John Lever, Robert Lew, Rabi Simantov, F. Ivy Carroll, Anita H. Lewin, Abraham Philip, Yigong Gao, Michael J. Kuhar

Research output: Contribution to journalArticlepeer-review

Abstract

Because some evidence suggests that cocaine and GBR12935 bind to different sites, we utilized photoaffinity probes from both classes of compounds to see if they label the same protein. [125I]RTI-82 a cocaine analog, and [125I]DEEP, a GBR analog, labeled protein(s) showing the same molecular weight, a similar pharmacological profile and a similar sensitivity to neuraminidase.

Original languageEnglish (US)
Pages (from-to)173-174
Number of pages2
JournalBrain research
Volume576
Issue number1
DOIs
StatePublished - Mar 27 1992

Keywords

  • Cocaine
  • DEEP
  • Dopamine transporter
  • Dopamine uptake
  • Photoaffinity labeling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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