A cluster of microvillous inclusion disease in the Navajo population

John F. Pohl, Mitchell D. Shub, Eric E. Trevelline, Kristy Ingebo, Gary Silber, Nancy Rayborn, Steve Holve, Diana Hu

Research output: Contribution to journalArticlepeer-review

Abstract

We report 4 unrelated patients with characteristic microscopic findings of microvillous inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child with MID. The unusually high incidence in this population indicates that a founder effect might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It is recommended that all Navajo infants presenting with severe diarrhea during early infancy undergo investigation for MID.

Original languageEnglish (US)
Pages (from-to)103-106
Number of pages4
JournalJournal of Pediatrics
Volume134
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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