A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: Multiple activities of interleukin 3

D. M. Rennick, F. D. Lee, T. Yokota, K. I. Arai, H. Cantor, G. J. Nabel

Research output: Contribution to journalArticle

Abstract

We recently isolated from a mouse T cell cDNA library a full-length clone that encodes a mast cell growth factor (1). On the basis of sequence homologies, this cloned factor must be similar if not identical to purified interleukin 3 (IL 3) (2, 3). Here, we report the first biologic characterization of the cloned gene product expressed in COS-7 monkey cells. Our results establish that a single molecular species promotes the growth and differentiation of a wide spectrum of hematopoietic cell types, including multipotential stem cells and various committed progenitor cells. The relationship of cloned IL 3 to other colony-stimulating factors is discussed.

Original languageEnglish (US)
Pages (from-to)910-914
Number of pages5
JournalJournal of Immunology
Volume134
Issue number2
StatePublished - 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Rennick, D. M., Lee, F. D., Yokota, T., Arai, K. I., Cantor, H., & Nabel, G. J. (1985). A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: Multiple activities of interleukin 3. Journal of Immunology, 134(2), 910-914.