Abstract
We recently isolated from a mouse T cell cDNA library a full-length clone that encodes a mast cell growth factor (1). On the basis of sequence homologies, this cloned factor must be similar if not identical to purified interleukin 3 (IL 3) (2, 3). Here, we report the first biologic characterization of the cloned gene product expressed in COS-7 monkey cells. Our results establish that a single molecular species promotes the growth and differentiation of a wide spectrum of hematopoietic cell types, including multipotential stem cells and various committed progenitor cells. The relationship of cloned IL 3 to other colony-stimulating factors is discussed.
Original language | English (US) |
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Pages (from-to) | 910-914 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 134 |
Issue number | 2 |
State | Published - 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology