A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion

G. Nabel, W. J. Allard, H. Cantor

Research output: Contribution to journalArticlepeer-review

Abstract

We previously described a cloned cell line that combines information for a unique display of cell surface antigens and specialized function similar to activated natural killer (NK) cells. In addition to conventional cellular targets such as the YAC-1 and MBL-2 lymphomas, this cloned line also lysed lipopolysaccharide-activated B lymphocytes. To determine whether some NK cells can inhibit B cell function, we tested the ability of NK-like clones to suppress Ig secretion in vitro and in vivo. These cloned cells suppressed Ig secretion when they constituted as few as 0.2% of the total cell population and inhibition did not require identity at the H-2 locus. We suggest that some NK cells might recognize non-major histocompatibility complex gene products on activated B lymphocytes and lyse these cells, and this might represent a fundamental cell-cell interaction that regulates antibody secretion by activated B cells.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalJournal of Experimental Medicine
Volume156
Issue number2
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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